ObjectiveTo compare the short-term effectiveness of femoral prosthesis with different neck-shaft angles for the reconstruction of proximal femoral anatomy after total hip arthroplasty (THA). MethodsBetween January 2012 and December 2013, 101 patients undergoing unilateral THA who accorded with selection criteria were selected for a retrospective study. The patients were divided into 2 groups:during THA, femoral prosthesis with 135° neck-shaft angle was used in 52 patients (group A) and femoral prosthesis with 127° neck-shaft angle was used in 49 patients (group B). There was no significant difference in gender, age, weight, body masss index, pathogeny, disease duration, preoperative neck-shaft angle, leg discrepancy, and preoperative Harris score between 2 groups (P>0.05). The postoperative Harris score was recorded to evaluate the effectiveness. And the femoral offset of the operated and contralateral sides, the change value of the femoral offset (xFO), the ratio of xFO to the offset of contralateral side (sdFO), the number of patients whose sdFO was more than 15% or less than -15% (outlier), the global offset, the height of femoral head rotation center, and leg discrepancy were measured at postoperation. ResultsOperative incision healed by first intension in 2 groups; no complication of infection, dislocation, or revision was found. All patients were followed up 12-32 months (mean, 23 months). The Harris score at last follow-up were significantly improved when compared with preoperative score in 2 groups (P＜0.05), but there was no signficant difference between 2 groups (t=1.267, P=0.832). The xFO and sdFO of group B were significantly larger than those of group A (P＜0.05); the number of outlier was 20 in group A and was 33 in group B, showing significant difference (P=0.005). The height of femoral head rotating center and global offset at 3 months after operation showed no signficant difference between 2 groups (P>0.05). And significant improvement in leg discrepancy was found at 3 months in 2 groups (P＜0.05), but there was no significant difference between 2 groups (t=0.403, P=0.689). ConclusionBoth of the two femoral prosthesis with different neck-shaft angles can restore the proximal femoral anatomy well and gain similar early effectiveness after THA. However, the Stryker Trident femoral prosthesis with 127° neck-shaft angle may have the tendency to enlarge the femoral offset.