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find Author "QIAN Haixin" 1 results
  • Expression and Clinical Significance of TGF-β1 and p27 in Gallbladder Carcinoma

    【Abstract】Objective To investigate the expression of tumor growth tactor β1 (TGFβ1) and p27 in gallbladder carcinoma and their relation to the development of the carcinoma. Methods The expression of TGF-β1 and p27 in 36 cases of gallbladder carcinoma was detected by SP immunohistochemical staining. Twenty cases of chronic cholecystitis were collected as control. Results The positive rate of TGF-β1 (63.9%) was higher than that of the control (10.0%),P<0.05, and the positive rate of p27 (47.2%) was lower than that of the control 100%(P<0.05). The positive rate of TGF-β1 was significantly higher in metastasis or Nevin Ⅳ~Ⅴ stage cases than that of non-metastasis or Nevin Ⅰ~Ⅲ stage cases 33.3% (P<0.05). The positive rate of p27 was statistically higher in moderate and highly differentiation (60.9%), nonmetastasis (75.0%) or Nevin’s Ⅰ~Ⅲ stage (75.0%) cases than those of poor differentiation (23.0%), metastasis (33.3%) and Nevin Ⅳ~Ⅴ stage (33.3%) cases (P<0.05). The expression of p27 was negatively correlated with that of TGF-β1(r=-0.4473,P<0.05). There was significant difference in survival time between patients with TGF-β1 positive and TGF-β1 negative(P<0.05). The difference was also found between patients with p27 positive and p27 negative. Conclusion The upregulation of TGF-β1 and downregulation of p27 in gallbladder carcinoma indicates the imbalance of TGF-β1/p27 system, which may play a role in the carcinogenesis and predict the malignant behaviors of the carcinoma.

    Release date:2016-08-28 04:44 Export PDF Favorites Scan
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