ObjectiveTo explore drug resistance, resistant mechanisms and resistant phenotypes of staphylococcus aureus (SA) isolated from wound secretion to macrolides-lincosamides-streptogramins (MLS). MethodsA retrospective design was used to collect clinical data and antimicrobial resistance profiles of SA in the First Affiliated Hospital and the Second Affiliated Hospital of Fujian Medical University and Anxi County Hospital from June, 2008 to October, 2015. SPSS 19.0 software was used for data analysis. ResultsA total of 127 isolates were included. The distribution of four resistant phenotypes of SA to MLS were all susceptibility(S) type (n=48, 37.8%), ML type (n=41, 32.3%), M/iCR+ type (n=22, 17.3%) and MLS type (n=16, 12.6%), respectively; There were three kinds of phenotypes caused by target changing including ML type, M/iCR+ type and MLS type, respectively. Moreover, no moxicaxin, linezolid or tigecyline resistant strain was detected, while quinolons and tetracyclines showed low-level resistant. ConclusionCompared with the different samples, the resistant phenotypes of SA isolated from wound secretion to MLS are few, and the total resistance ratio is low.