Objective To investigate the correlation between RUNX3 expression and human gastric cancer, as well as its clinically pathologic features. Methods Such databases as PubMed, EMbase, VIP, WanFang Data and CBM were searched from their inception to February 28th, 2013 to collect case-control studies about the correlation between RUNX3 expression and human gastric cancer, as well as its clinically pathologic features, and the relevant references of the included literature were also retrieved. Two reviewers independently screened the literature according to the inclusion and exclusion criteria, extracted the data, and assessed the methodological quality. Then meta-analysis was conducted using RevMan 5.0 software. Results A total of 6 case-control studies were included, which included 405 cases in the gastric cancer group and 185 cases in the normal gastric mucosa group. The results of meta-analysis showed that, RUNX3 expression was lower in the gastric cancer group than the normal gastric mucosa group, with a significant difference (OR=0.07, 95%CI 0.04 to 0.12, Plt;0.000 01); it was also lower in the subgroup of gastric cancer accompanied with lymph node metastasis than that without lymph node metastasis (OR=0.37, 95%CI 0.23 to 0.61, Plt;0.000 1); but it was higher in the subgroup of gastric cancer that had infiltrated into serosa than that had not, with a significant difference (OR=3.92, 95%CI 2.29 to 6.71, Plt;0.000 01); and it was also higher in the subgroup of well differentiated gastric cancer that the moderately and poorly differentiated, with a significant difference (OR=0.36, 95%CI 0.22 to 0.58, Plt;0.000 1). Conclusion RUNX3 expression is notably correlated to gastric cancer and its clinically pathologic features. For the quantity and quality limitation of the included studies, this conclusion still needs to be further proved by performing more high quality studies.
ObjectiveTo systematically review the correlation between RUNX3 expression of colorectal cancer and its clinical characteristics. MethodsDatabases including PubMed, The Cochrane Library (Issue 9, 2013), EMbase, MEDLINE (Ovid), CNKI, VIP, WanFang Data and CBM were searched for collecting published international and domestic case-control studies on the correlation between RUNX3 expression of colorectal cancer and its clinical characteristics from the date of their establishment to October 1st, 2013. Two reviewers screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the methodological quality of the included studies. Then, meta-analysis was performed using RevMan 5.2 software. ResultsA total of 7 case-control studies were included involving 804 cases in total (521 cases in colorectal cancer group and 383 cases in control group). The results of meta-analysis showed that, RUNX3 expression was lower in the colorectal cancer group than in the normal control group (OR=0.05, 95%CI 0.03 to 0.08, P < 0.000 01); higher in the moderately/highly-differentiated group than in the poorly differentiated group (OR=4.77, 95%CI 2.88 to 7.90, P < 0.000 01); higher in colorectal cancer with invasion depth on T1-T2 stage than in that on T3-T4 stage (OR=8.13, 95%CI 4.15 to 15.92, P < 0.000 01); and lower in the colorectal cancer accompanied with lymph node metastasis than that without lymph node metastasis (OR=0.23, 95%CI 0.14 to 0.36, P < 0.000 01), all with significant differences. No significant difference was found in RUNX3 expression between groups by age, sex and tumour location. ConclusionRUNX3 expression is notably correlated to colorectal cancer and its clinical characteristics. Due to the quantity and quality limitation of the included studies, the above conclusion still needs to be further proved by performing more high quality studies.