ObjectiveTo compare the effectiveness of lateral approach minimally invasive plate osteosynthesis (MIPO) and helical plate MIPO in the treatment of proximal humeral shaft fractures. Methods The clinical data of patients with proximal humeral shaft fractures who underwent MIPO via lateral approach (group A, 25 cases) and MIPO with helical plate (group B, 30 cases) between December 2009 and April 2021 were retrospectively analyzed. There was no significant difference in gender, age, injured side, cause of injury, American Orthopaedic Trauma Association (OTA) fracture classification, and time from fracture to operation between the two groups (P>0.05). The operation time, intraoperative blood loss, fluoroscopy times, and complications were compared between two groups. The angular deformity and the fracture healing were evaluated according to anteroposterior and lateral X-ray films postoperatively. The modified University of California Los Angeles (UCLA) score for shoulder and the Mayo Elbow Performance (MEP) score for elbow were analyzed at last follow-up. Results The operation time in group A was significantly shorter than that in group B (P<0.05). However, the intraoperative blood loss and fluoroscopy times presented no significant difference between the two groups (P>0.05). All patients were followed up 12-90 months, with an average of 19.4 months. There was no significant difference in follow-up time between the two groups (P>0.05). In terms of the quality of postoperative fracture reduction, there were 4 (16.0%) and 11 (36.7%) patients with angulation deformity in group A and group B, respectively, and there was no significant difference in the incidence of angulation deformity (χ2=2.936, P=0.087). All fractures achieved bony union, there was no significant difference in fracture healing time between group A and group B (P>0.05); delayed union occurred in 2 cases and 1 case in group A and group B, respectively (healing time was 30, 42, and 36 weeks after operation, respectively). In group A and group B, 1 patient had superficial infection of incision, respectively; 2 patients and 1 patient had subacromial impact after operation, respectively; and 3 patients in group A had symptoms of radial nerve paralysis of different degrees; all of them were cured after symptomatic treatment. The overall complication incidence of group A (32%) was significantly higher than that of group B (10%) (χ2=4.125, P=0.042). At last follow-up, there was no significant difference in the modified UCLA score and MEPs score between the two groups (P>0.05). Conclusion Both lateral approach MIPO and helical plate MIPO can achieve satisfied effectiveness in the treatment of proximal humeral shaft fractures. Lateral approach MIPO may be beneficial to shorten the operation time, while the overall complication incidence of helical plate MIPO is lower.
ObjectiveTo investigate the research progress of residual nodules after thermal ablation for benign thyroid nodules.MethodsThe domestic and foreign guidelines and consensus on the treatment of benign thyroid nodules were collected, and the indications for thermal ablation were summarized. The causes of residual nodules after ablation were analyzed, the characteristics of residual nodules were evaluated through multiple approaches, and the follow-up treatment measures were summarized.ResultsThe indications of thermal ablation of benign thyroid nodules were different at home and abroad. The causes of residual nodules included slow absorption after ablation and incomplete ablation. Among the evaluation methods of residual nodules, the nodules volume reduction rate was the evaluation standard of short-term efficacy, contrast-enhanced ultrasound was the best method, color Doppler blood color distributionwas the most commonly used method, elastic imaging was a valuable method, and puncture pathology biopsy was an important standard. Reablation and surgical resection were the follow-up treatments for residual nodules.ConclusionsAs a new technique, thermal ablation of benign thyroid nodules has some advantages, but it is flooding at present. In the future, it is necessary to standardize indications, improve the efficiency of first ablation, attach importance to pathological complete ablation, and reasonably evaluate the treatment of residual nodules, so that thermal ablation of benign thyroid nodules could reflect rationality, safety, and efficiency, and give full play to its advantages, so as to serve patients better and have better application prospects.
Magnetic ferrite nanoparticles (MFNPs) have great application potential in biomedical fields such as magnetic resonance imaging, targeted drugs, magnetothermal therapy and gene delivery. MFNPs can migrate under the action of a magnetic field and target specific cells or tissues. However, to apply MFNPs to organisms, further modifications on the surface of MFNPs are required. In this paper, the common modification methods of MFNPs are reviewed, their applications in medical fields such as bioimaging, medical detection, and biotherapy are summarized, and the future application directions of MFNPs are further prospected.