ObjectiveTo investigate the interventive effect of xuebijing for injection combined with nalmefene hydrochloride injection in treatment of acute hepatocyte functional injury after severe thoracoabdominal injuries. MethodsClinal data of 169 patients with severe thoracoabdominal injuries who treated in The 253th Hospital of PLA between January 2009 and June 2013 were collected retrospectively. The trauma indexes of the 169 patients were all higher than 17 scores. Patients were divided into the intervention group (n=112) and the control group (n=57) according to their receptive treatment:patients of control group underwent traditional treatments such as antishock, hemostasis, and so on; but patients of intervention group received xuebijing for injection combined with nalmefene hydrochloride injection (intravenous infusion). Patients of intervention group were tested at the time of arriving at and leaving the emergency department to the inpatient department with alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α), lipopolysaccharide (LPS), and interleukin-6 (IL-6); the patients of control group were just tested at the time of leaving the emergency department to the inpatient department, then comparison of the indexes between the 2 groups was performed. ResultsIn intervention group, the levels of ALT, AST, TNF-α, LPS, and IL-6 after the interventive treatment were all lower than those of before interventive treatment (P<0.05). Compared with control group, there was no significant difference in the levels of ALT, AST, TNF-α, LPS, and IL-6 before the interventive treatment of intervention group (P>0.05); but the levels ALT, AST, TNF-α, LPS, and IL-6 were all lower after the interven-tive treatment (P<0.05). ConclusionsXuebijing for injection combined with nalmefene hydrochloride injection can evidently improve the acute hepatocyte functional injury after severe thoracoabdominal injuries, and improve the prognosis.