Objective To investigate the effects of the nerve, endocrine, and immune factors on the process of wound healing and regeneration of the skin after injury and to review the research work in the past years in this area. Methods The prospective study was made to explore the relationship among the nerve, endocrine, immune factors, and skin tissue repair and regeneration, and to summarize the recent advance in this area. Results The nerve, endocrine, and immune factors played an important role in the repair and generation of the skin after injury. Conclusion As there has been fewer studies made in this field, we should reinforce the related basic research in this field.
ObjectiveTo review the role of microRNA (miRNA) in skin development and wound healing. MethodsThe recent literature about miRNA in skin development and wound healing was reviewed and analyzed. ResultsmiRNA extensively involved in the development of the skin,including epidermal cell proliferation,differentiation,aging and hair follicle development;miR-203 known as the "skin-specific miRNA" can directly inhibit the expression of p63 and promote the differentiation of the epidermis.Meanwhile,miRNA also involved in various stages of skin regeneration and wound healing.Abnormal expression of miRNA is closely related with abnormal wound healing. ConclusionmiRNA play an important role in maintaining normal skin physiology and skin regeneration.To explore their roles in the healing of skin wounds and their regulatory mechanism can provide a new target for the treatment,which has a potential value and broad prospects.