west china medical publishers
Keyword
  • Title
  • Author
  • Keyword
  • Abstract
Advance search
Advance search

Search

find Keyword "Soluble triggering receptor expression on myeloid cells-1" 1 results
  • Expression of Soluble Triggering Receptor Expression on Myeloid Cells-1 in Sepsis Patients and Its Clinical Implication

    Objective To investigate the expression and clinical significance of soluble triggering receptor expression on myeloid cells-1(sTREM-1) in sepsis patients.Methods Serum concentrations of sTREM-1,procalcitonin(PCT),tumor necrosis factor alpha(TNF-α) and interleukin-10(IL-10) were measured by enzyme-linked immunosorbent assay,while high sensitivity C-reactive protein (hsCRP) level was detected by immunoturbidimetry in 68 patients with sepsis,40 patients with no-infective SIRS,and 20 normal individuals. The diagnostic and prognostic value of sTREM-1 and its comparison with PCT and hsCRP were analyzed. The sequential organ failure assessment (SOFA) score system was used to evaluate the severity of sepsis. The relationship between sTREM-1, PCT , hsCRP , SOFA score,TNF-α ,and IL-10 of the sepsis patients was analyzed,respectively. Results The differences in the serum concentrations of sTREM-1,PCT,hsCRP,IL-10 and IL-10/TNF-α ratio had statistical significance among three groups(Plt;0.05). The differences in the serum concentration of TNF-α had no statistical significance among three groups (Pgt;0.05). However,the serum levels of sTREM-1,PCT and hsCRP in the sepsis group were significantly higher than those in the SIRS group (Plt;0.05). The receiver operating characteristic curve (ROC) analysis showed the area under the curve (AUC) for sTREM-1,PCT and hsCRP were 0.772 (95%CI 0.674-0.871),0.718 (95%CI 0.601-0.835) and 0.664 (95%CI 0.532-0.797),respectively. The serum levels of sTREM-1 and PCT in the non-survivors were significantly higher than the survivors in the sepsis group (Plt;0.01),but the differences in the serum concentration of hsCRP had no statistical significance between the non-survivors and the survivors in the sepsis group (Pgt;0.05). There were significantly positive correlations between sTREM-1 and SOFA score,IL-10 or IL-10/TNF-α ratio(r value of 0.453,0.301,0.417,Plt;0.05),but no correlation between sTREM-1 and TNF-α(Pgt;0.05). There was significantly positive correlation between PCT and SOFA score (r=0.436,Plt;0.05),while no relationship between hsCRP and SOFA score(Pgt;0.05). Conclusions The serum level of sTREM-1 not only be valuable in the diagnosis of sepsis,but also may be used as a prognostic marker in sepsis,as it can reflect the severity of sepsis in certain degree. Furthermore,sTREM-1 or PCT may be superior to hsCRP in diagnosis,prognostic judgment and severity assessment of sepsis.

    Release date:2016-08-30 11:58 Export PDF Favorites Scan
1 pages Previous 1 Next

Format

Content