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find Keyword "T cell immunology" 1 results
  • Clinical Implication on Expression of HLA Class I in Breast Cancer Tissures

    Objective To investigate the clinical implication on expression of HLA class I in breast cancer tissures.Methods The expression of HLA class I in 271 patients with breast cancer that underwent radical operation was examinedby using immunohistochemically, and the correlation between the expression of HLA class I and clinicalpathological characteristics and prognosis of breast cancer was analyzed. Results The b positive expression of HLA class I in breast cancer tissures was observed in 92 patients (33.9%), the expressions of HLA class I in 179 patients (66.1%)were downregulation. The expression of HLA class I expression in breast cancer tissures was significantly associated with the axillary lymph node metastasis, TNM stage (P<0.05), other lymph node metastasis, and vascular invasion (P<0.05). The disease free survival rate of patients with positive expression of HLA class I was higher than that expression downregulation of HLA class I (P<0.05). Conclusion The examination of HLA class I expression is useful for the prediction of tumor progression and recurrent risk of breast cancer via the antitumor immune system.

    Release date:2016-09-08 10:24 Export PDF Favorites Scan
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