Objective To investigate the application of quality control circle (QCC) activities in improving weight management ability of patients with renal edema. Methods A QCC activity group was founded, and " improving weight management ability of edema patients with kidney disease” was selected as the theme. Then the status of weight management ability in 51 patients with renal edema who were admitted to the Department of Nephrology from April 1st to 30th 2015 was investigated, the reasons of the low weight management ability were analyzed, and then appropriate countermeasures were carried out. After this activity, the status of weight management ability in 54 patients with renal edema who were admitted to the Department of Nephrology from October 1st to 31th 2015 was investigated, to assess the effect and consolidate the results of activities. Result After the QCC activities, the scores of weight management ability increased from 23.84±6.34 to 28.43±4.08 with statistical significance (P<0.05), and the qualified rate of weight management ability increased from 25.5% to 44.4% with statistical significance (P<0.05). Conclusion QCC activities can improve the weight management ability and the qualified rate of weight management ability of patients with renal edema, at the same time, it can improve the overall quality of nurses.