ObjectiveTo assess the efficacy and safety of Tiao-She nursing of traditional Chinese medicine (TCM) for mild cognitive disorder (MCD), and to provide theoretical basis for developing evidence-based guideline of Tiao-She nursing of TCM. MethodsWe searched PubMed, Web of Science, The Cochrane Library, EMbase, MEDLINE, Springerlink, CBM, CNKI, VIP and WanFang Data for systematic reviews/meta-analyses (SRs/MAs), as well as randomized controlled trials (RCTs), up to December 2014. Two reviewers screened literature according to the inclusion and exclusion criteria and extracted data. Methodological quality and evidence quality of included SRs/MAs were assessed using AMSTAR scale and GRADE tool, respectively. Methodological quality of included RCTs was assessed using risk of bias assessment tool of the Cochrane Handbook 5.1.0. ResultsNine RCTs were identified, but no SRs/MAs was retrieved. Interventions for MCD included acupoint massage, moxibustion, auricular-plaster therapy, qigong, Tai chi, calligraphy, and food therapy of ginseng. All included RCTs showed that Tiao-She nursing of TCM was effective on cognitive ability and psychosocial function. ConclusionTiao-She nursing of TCM might be effective and safe, and the methods are variable. Due to the limitation of the quality of included RCTs, the efficacy and safety of Tiao-She nursing of TCM for MCD are still needed to be verified by high quality studies.