ObjectiveTo explore the clinical value of dual-source CT perfusion imaging (CTPI) in the assessment of cerebral hemodynamic changes in patients with internal carotid atherosclerosis. MethodsThirty patients diagnosed to have internal carotid atherosclerosis by CT angiography examination with various degrees of stenosis or occlusion were treated between January 2012 and May 2013. Whole brain perfusion imaging was performed on all the patients. We rebuilt the CTPI figure parameters respectively, including cerebral blood volume (CBV), blood flow (CBF), mean transit time (MTT) and time to peak (TTP) to assess brain tissue perfusion. ResultsIn the 30 patients with internal carotid atherosclerosis, 8 had mild stenosis lumen, 12 moderate stenosis, 7 severe stenosis and 3 had occlusion. In mild stenosis cases, TTP of stenosis-side vessels was higher than those of coutralateral side (P<0.05), and there were no significant differences in other perfusion parameters between bilateral vessels among mild stenosis cases (P>0.05). MTT and TTP of stenosis-side vessels were higher than those of contralateral side in moderate stenosis cases (P<0.05). In severe stenosis or obstruction cases, MTT and TTP of stenosis-side vessels were higher than those of contralateral side, while CBF and CBV of stenosis-side vessels were lower than contralateral side (P<0.05). Twenty-two in the 30 cases had perfusion abnormalities, and there was a significant difference between the stenosis side cerebral perfusion and the healthy side mirror area (P<0.05). ConclusionCTPI can reflect brain tissue perfusion early and comprehensively, and fully reflect internal carotid atherosclerosis caused by severe stenosis or occlusion of cerebral hemodynamic changes, which provides important information for clinical treatment and helps clinicians to formulate individualized treatment plan.
ObjectiveTo evaluate the value of computed tomography examination in the clinical diagnosis guidance and therapeutic effect assessment for patients with uremic pneumonia. MethodsWe reviewed the clinical situation and pathogenesis turnover of 64 cases of uremic pneumonia from February 2011 to January 2013,and analyzed the correlation between image modification and treatment effectiveness. ResultsSixty-four cases of uremic pneumonia had different image manifestations in each phase of the disease course,including 27 cases of pulmonary venous pleonaemia,51 of lung interstitial edema,8 of pulmonary alveoli effusion,and 15 of pulmonary interstitial fibrosis.Dropsy of serous cavity and the heart shape could be viewed by CT scanning.CT rechecking was carried out after hemodialysis and symptom-targeted treatment.The results showed that CT results of 27 cases of pulmonary venous pleonaemia,51 cases of edema in the interstitial tissue and 41 cases of pleural effusion changed significantly after treatment (P<0.001);the image manifestations of 8 cases of pulmonary alveoli edema also changed significantly (P<0.05);the CT result of 15 cases of pulmonary interstitial fibrosis had no change;six cases among the fourteen cases of pericardial effusion were not absorbed by treatment (P>0.05). ConclusionThe diagnosis of uremic pneumonia mainly depends on imaging results.CT scanning plays an important role on the determination of clinical stage,the choice of therapeutic method,and evaluation of curative effect for uremic pneumonia.