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find Keyword "Tongxiening granule" 1 results
  • Tongxiening Granule in the Treatment of Diarrhea-predominant Irritable Bowel Syndrome ( Stagnation of the Liver-Qi Attacking the Spleen):A Prospective, Randomized, Placebo-controlled, Double-blind Clinical Trial

    Objective To evaluate the efficacy and safety of Tongxiening granule (TXNG) in the treatment of diarrhea-predominant irritable bowel syndrome (IBS) (stagnation of the liver-qi attacking the spleen). Methods In a prospective, randomized, placebo-controlled, double-blind clinical trial, 60 patients with diarrhea-predominant IBS were randomly divided into the TXNG group (TXNG, 5.0g, 3 times daily; n =30) and the placebo group (placebo, 5. 0g, 3 times daily; n =30). The treatment was administered for 3 weeks, and the follow-up was conducted for 4 weeks.Results (1)Abdominal pain: The cure rates were 57. 7% vs. 16. 0% ( by per-protocol analysis, PP) and 31.0% vs. 7.1% ( by intention-to-treat analysis (ITT) ; and the overall improvement rates were 92.3% vs. 44.0% (PP) and 82.7% vs. 39.3% (ITT) in the TXNG and the placebo groups respectively ( P 〈0. 05). (2) Diarrhea : the cure rates were 46. 2% vs. 20. 0% (PP) and 41.4% vs. 17. 9% (ITT) , and the overall improvement rates were 96. 2% vs 48. 0% (PP) and 86. 2% vs 42.9% (ITT) in the two groups respectively (P 〈0.05). (3)Traditional Chinese medicine symptoms: the cure rates were 30.8% vs. 4.0% (PP) and 27.6% vs. 3.6% (ITT) ; and the overall improevment rates were 92.3% vs. 48.0% (PP) and 82.7% vs 42.9% (ITT) in the two groups respectively (P 〈0. 05). The pain duration after treatment in the TXNG group was significantly shortened compared with the placebo group (7.6 ±4. 6d vs 14. 4 ±4. 3d, P =0. 0125). After 4-week follow-up, it suggested that the recrudescent duration in symptoms related to IBS in the TXNG group was longer than that in the placebo group (11.5 ±5.3 d vs 6.2 ±6.9 d, P = 0. 019). No adverse effects were found in the TXNG group. Conclusion It was demonstrated that TXNG is effective and safe in the treatment of diarrhea-predominant ms (stagnation of the liver-qi attacking the spleen).

    Release date:2016-09-07 02:17 Export PDF Favorites Scan
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