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抗肿瘤坏死因子α抗体对体外循环肺损伤的保护作用

Objective To study the protective effect and its mechanism of anti-tumor necrosis factor-alpha antibody (TNF-α Ab) on lung injury after cardiopulmonary bypass(CPB). Methods Twenty patients who underwent cardiac valve replacement were randomly divided into two groups (each group 10 cases).TNF-α Ab group: human TNF-α Ab (1.2μg/kg) was twice dropped into the intracheal tube before operation and just after releasing the aortic clamp. Control group: only received CPB. Lung dynamic compliance, oxygenation index, endotracheal intubation time, blood neutrophils count, TNF-α, and malondialdehyde (MDA) from the right and left atrium in both groups were determined perioperatively. Results Lung dynamic compliance and oxygenationindex in TNF-α Ab group after CPB were higher than those in control group(Plt;0.01). The endotracheal intubation time in TNF-α Ab group was much shorter than that in control group(Plt;0.01). Compared with control group, TNF-α Ab can significantly restrain leukocyte accumu lation, reduce releasing of TNF-α and MDA in the lung. Conclusion Intratracheal TNF-α Ab has markedly protective effect on lung injury after CPB.