Objective To analyze the risk factors and clinical characteristics of patients in Uyghur and Han nationalities with pulmonary thromboembolism (PTE), who were hospitalized in past 7 years in the First Affiliated Hospital of Xinjiang Medical University, so as to investigate differences of risk factors between two nationalities. Methods Through retrospective study, clinical characteristics of PTE patients hospitalized from 2004 to 2010 were analyzed. T-test and chi-square test were used to conduct statistic analysis. Results a) A total of 516 patients (mean age 58.7±14.8 years old) with complete clinical materials were included, of whom 360 were Han nationality (69.8%, mean age 63.5±15.5 years old) and 156 were Uyghur nationality (30.2%, mean age 52.8±14.3 years old). In Han nationality, the peak age of PTE onset was above 70 years of age, while in Uyghur nationality it was 60 to 69 years of age; b) No significant difference was found in the clinical characteristics between the two nationalities; and c) The commonly acquired risk factors for PET patients in both nationalities possibly were age at or over 40 years old, obesity, embolism history and hyperlipidemia. The main risk factor of PTE was obesity in Uyghur nationality, while that was smoking in Han nationality. Conclusion The most common acquired risk factors and basic diseases of PTE patients are probably the age at or over 40 years old, obesity, embolism history and hyperlipidemia, and obesity is commonly seen in Uyghur nationality. A large number of further case-control studies are needed to further confirm this conclusion.
ObjectiveTo comparatively analyze risk factors that influence the postoperative recurrence and distant metastasis between Xinjiang Uygur and Han women with breast cancer. MethodsThe clinical data of Han and Uyghur women with diagnosis of breast cancer at Ⅰ-Ⅲ period were completely collected for retrospective analysis. Then logistic regression (univariate and multivariate) was performed for analyzing the risk factors that influenced recurrence and metastasis. ResultsA total of 728 patients were included. The recurrence and metastasis rates among Uyghur and Han patients 3 years after surgery were 28.4%, 9.8%, respectively, including local recurrence[11 Uyghur cases (6.5%) and 9 Han cases (1.6%)] and distant metastasis[37 Uyghur cases (21.8%) and 45 Han cases (8.0%)]. Significant differences were found between the two groups in tumour size and time from symptom occurrence to clinical visits (P<0.05). Pathological type, tumour size, axillary lymph node metastasis, clinical stage, ER and PR expression, and whether to accept a regular postoperative adjuvant therapy were associated with the recurrence and metastasis rate among the patients with breast cancer at Ⅰ-Ⅲ period (P<0.05). The results of multivariate logistic regression analysis showed that, the recurrence and metastasis rate of Uyghur patients was higher than that of Han patients with a significant difference (P<0.01). Pathological type, tumour size, and axillary lymph node metastasis number were the risk factors used to predict postoperative recurrence and metastasis among Uygur and Han patients; while ER positive expression, adjuvant radiation and postoperative chemotherapy were protective factors. ConclusionThe recurrence and metastasis rate of Uyghur patients with breast cancer is higher than that of Han patients. Pathological type, tumour size, and axillary lymph node metastasis number are the risk factors of postoperative recurrence and distant metastasis; while ER positive expression, adjuvant radiation and postoperative chemotherapy may inhibit the recurrence and distant metastasis of breast cancer.