The clinical comprehensive evaluation of drugs is a fundamental work that promotes drugs return to clinical value and it has become one of the most important clinical pharmacy researches in recent years. The existing literatures focuses on the construction of clinical comprehensive evaluation index system or the quantification of index value. But, there is relatively little literatures about the value integration method, which may lead to the suboptimal scheme is selected as the optimal scheme. Therefore, this study summarizes various comprehensive value integration methods from the aspects of background, principles and applicable situations, to provide methodological references for clinical comprehensive evaluation in China.