Objective To report the screening, prevention and treatment of venous thrombosis for Lushan earthquake victims in the West China Hospital of Sichuan University. Methods Among the Lushan earthquake victims screened by vascular color Doppler, those with detected venous thrombosis were treated reasonably, and those without detected venous thrombosis were prevented early. Results There were total 235 Lushan earthquake victims in the hospital as of the 11th day after earthquake, and they were screened by vascular color Doppler. Among 26 cases with detected venous thrombosis, 25 were lower limb venous thrombosis, and the other one was upper limb venous thrombosis. Three cases were treated by rehabilitation intervention alone, three cases were treated by drug intervention alone, and the other 20 cases were treated by both rehabilitation and drug intervention. As of 30 days after the earthquake, the reexamination results of 26 victims with venous thrombosis showed that: 11 cases improved, including 5 completely recanalization and 6 incompletely recanalization. Among the three cases with drug intervention alone, one got completely recanalization, accounted for 33.33%. Among the three cases with rehabilitation intervention alone, one got incompletely recanalization, accounted for 33.33%. Among the 20 cases with both rehabilitation and drug intervention, four got completely recanalization, accounted for 20.0%, and five got incompletely recanalization, accounted for 25.0%. Conclusion Most Lushan earthquake victims with venous thrombosis are the elderly and women, stay in the ICU, and suffer from fractures in different degrees. The timely prevention and treatment can relieve local pain, promote early entry in the rehabilitation treatment, and prevent pulmonary embolism and other risks. The rehabilitation intervention and/or drug intervention should be adopted to the victims with detected venous thrombosis as well as the victims without detected venous thrombosis but have high risk factors, for it can effectively prevent and treat the further thrombosis and other bad consequences of the detachment of thrombus.
ObjectiveTo investigate the risk factors for lower limbs deep venous thrombosis(LDVT), and provide reference for the prevention and treatment of LDVT. MethodsThe pathogenic factors of 187 patients with LDVT in our hospital from 2010 to 2013 were retrospectively analyzed. ResultsOne hundred and eighty-seven patients with LDVT were 19-88 years old, mean 56.6 years old, and the age of onset was many in the 41-60 years old(65.2%). In 187 cases, male 102 cases, female 85 cases; left lower extremity in 112 cases, right lower extremity in 65 cases, and 10 cases of double lower limbs. LDVT predisposing factors were the lower extremities a history of fracture, surgery, tumor, bedridden, previous history of blood clots, and a small amount of internal diseases of unknown cause. ConclusionsLDVT occurs at 41-60 years old. The surgery, tumor, and history of thrombosis are independent risk factor of LDVT.
ObjectiveTo research the magnetic labeled endothelial progenitor cells(EPCs) transplanted into the rat of venous thrombosis model through the tail vein and track transplanted stem cells in vivo, provide an effective monitoring technology for promoting organization and recanalization of deep venous thrombosis. MethodsBone marrowderived EPCs were extracted, purified, and identified, then labeled with the new SPIO particles. At the same time, the inferior vena cava thrombus models in rats were made, which were randomly divided into four groups:SPIO group (EPCs labeled with SPIO transplantation), Dil group (EPCs labeled with Dil transplantation), control group (simple EPCs transplantation), and blank control group (1 mL medium transplantation). After transplantation, the MRI, HE staining, and immunohistochemical staining were performed and the capillary density was counted under high-power microscope. ResultsThe MRI showed that EPCs labeled with SPIO had migrated to the inferior vena cava thrombus and the mass of high signal shade was seen, with the extension of time, the signal strengthened gradually. On day 14-21, the signal became the strongest, then decreased gradually. The immunohistochemical staining and HE staining showed that there were a mass of the new capillary in the specimens of thrombus of the SPIO group, Dil group, and control group, the difference was not statistically significant among these three groups(P > 0.05), but which was significant difference as compared with blank control group (P < 0.05). ConclusionCompared with EPCs labeled with Dil, it
ObjectiveTo understand the initiation, maturing, and resolution of thrombus by comparing the length and weight of thrombus at different time in the rat inferior vena cava (IVC) stenosis model. MethodsForty-eight female Sprague Dawley rats, weighing 180-230 g, were selected to prepare the IVC stenosis model by blocking the most of the IVC blood flow. The length and weight of IVC thrombus were measured at different time points, the histological features were observed via HE staining. ResultsBlood clots formed after 2 hours of modeling, the thrombus length and weight showed no significant difference between at 2 hours and 4 hours after modeling (P>0.05). The thrombus length and weight increased significantly at 6 hours, showing significant differences between at 2 and 4 hours and at 6, 8, 12, 24, and 48 hours (P<0.05); and from 6 to 48 hours, there was no significant difference in the thrombus length and weight (P>0.05), indicating that thrombus was stable, or maturing. Blood clots began to become smaller after 3 days when compared with ones at 48 hours (P<0.05), indicating the start of resolution at 3 days. At 7 days, the thrombus length and weight became further smaller when compared with ones at 3 days (P<0.05). The thrombus completely subsided at 21 days, the IVC recanalized. HE staining showed that thrombus formed after 2 hours of modeling; from 6 to 48 hours, the lumen became hyperemia, and the inflammatory cells, especially neutrophils, could be found. The organization of thrombus could be observed at 3 days and 7 days; thrombus gradually vanished at 21 days. ConclusionThe time of thrombus initiation, maturing stage, and resolution stage is 6 hours, 6 to 48 hours, and 3 to 21 days after modeling, respectively.
Objective To investigate the clinical effect of percutaneous endovascular interventional treatment for bilateral iliofemoral venous thrombosis. Methods From November 2012 to February 2016, the clinical data of 18 patients with bilateral iliofemoral venous thrombosis were retrospectively analyzed. All patients including 7 males and 11 females, aged from 51 to 86 years with an average of (66.2±7.8) years old. All patients underwent interventional treatment, and mechanical aspiration thrombectomy was performed under the protection of inferior vena cava filter at the acute or subacute phase; those whose venography showed iliac vein stenosis received balloon dilatation and self-expandable stents immediately. Iliac vein stenosis received balloon dilatation and self-expandable stents immediately at the chronic phase. Results The treatment was successful in all patients. The circumference difference of thigh and calf was (7.3±2.1) and (4.6±2.7) cm respectively before and after treatment. Thirteen patients with stenosis or occlusion of the iliac vein were treated with adjunctive balloon dilatation and stent placement, and 20 self-expandable stents were inserted successfully. All the patients were followed up for 12–34 months with an average of (21.5±7.3) months; stenosis or occlusion of the stent were seen in 1 patient after 9 months; post thrombotic syndrome was observed in 1 patient after 12 months. The 12-month primary patency rate and secondary patency rate was 88.9% (16/18) and 100.0% (18/18), respectively. Conclusion Endovascular interventional therapy of bilateral iliofemoral venous thrombosis is a safe and effective method.