Spinal cord injury (SCI) patients are high-risk groups of hospitalized patients with venous thrombosis embolism (VTE). VTE is one of the important causes of inpatients’ unexpected death and perioperative accidental death, so SCI patients with VTE deserve special attention. In recent years, the risk factors, epidemiological characteristics, pathogenesis, and prevention of VTE have been further understood. We also have a more comprehensive and in-depth understanding of the treatment of venous thrombosis, including general prevention, drug, interventional surgery, rehabilitation, etc. Non-invasive examination, new therapeutic technologies, and new oral anticoagulant drugs have also greatly promoted the prevention and treatment of VTE. Meanwhile, prevention system of VTE has been developed from single subject work gradually to the multidisciplinary, multiple grades and doctor-patient cooperation mode, is no longer just dominated by clinical departments, but dominated by hospitals and even higher level department, and a more scientific and effective management mode has being under construction, all of these will further optimize the clinical prevention and treatment of venous thrombosis.