Objective To review the basic researches and the cl inical appl ication of the nano-neural tissue engineering materials, especially the electrically conductive carbon nanotubes (CNT). Methods The l iterature concerning the basic and cl inical researches of the conductive materials of nano-neural tissue engineering, especially the electrically conductive CNT were reviewed. Results The researches of conductive materials of nano-neural tissue engineering have made some progress, the electrically conductive CNT can not only promote Schwan cells’ adhension, migration, and prol iferation, but also mimic the function of electric conductivity of neural myel in and enhance neurite growth and regeneration. So the electrically conductive CNT make great sense in stimulating and directing the growth of neurite and the regeneration of axons. Conclusion Because of these unique properties, the electrically conductive CNT have great advantages in peripheral nerve repair and function reconstruction, and are promising to provide a novel method for cl inical peri pheral nerve repair and function reconstruction after injury.
Objective To review the research progress of electrospun nanofibers scaffold in nerve tissue engineering. Methods The related l iterature on electrospun nanofibers scaffold in nerve tissue engineering was extensively reviewed and analyzed. Results A variety of material nanofibers scaffolds can be fabricated through electrospinning. The chemical and physical properties of the scaffold can be modified and it was suitable for neuron. The scaffold can bridge the defect of peripheral nerve and partial function can be restored. Conclusion Electrospun nanofibers scaffold has broad appl ication prospects in nerve tissue engineering.