目的 探讨子宫内膜癌中雌激素受体（ER）、孕激素受体（PR）和p53的表达及其临床意义。 方法 1994年1月-2009年11月，应用免疫组织化学Envision法检测52例子宫内膜癌中ER、PR和p53的表达情况并进行统计学分析。 结果 ER、PR和p53阳性表达率分别为51.9%、50.0%和46.2%。ER、PR的阳性表达率与癌组织的细胞分化程度有关（Plt;0.05）。随着组织学分级的增高，ER、PR阳性表达率逐渐降低（在Ⅰ、Ⅱ和Ⅲ级子宫内膜癌中，ER阳性表达率分别为64.0%、56.3%和18.2%， PR阳性表达率分别为72.0%、37.5%和18.2%）。随着组织学分级的增高及淋巴结转移，p53的阳性表达率逐渐增高（Plt;0.05），p53表达与ER、PR表达有关（Plt;0.05）。 结论 ER、PR和p53的表达与子宫内膜癌组织学分级和生物学行为密切相关，其测定对评估子宫内膜癌预后，指导临床治疗具有重要意义。
Objective To get known the existing problems in rural primary physicians training in Gansu province, so as to explore an appropriate training mode for Gansu province. Methods This study conducted a comprehensive analysis by combining literature analysis, on-site survey and interview. Such databases as CNKI, VIP and CBM were searched to include literature published before November 2011, and the references of the included literature were also retrieved. The qualitative analysis was performed after assessing the methodological quality of the included literature according to self-designed criteria. Additionally, the rural primary hospitals in Gansu province were classified according to their geographical position and economic development level, total 10 township hospitals were randomly selected by cluster sampling, and the following stuffs participated various trainings in past 3 years were on-site-investigated: clinical doctors, nurses, medical technicians, and medical administrators, in aspects of training time, place, contents, modes, and effects. Results The existing problems in primary physicians training modes in Gansu were as follows: uneven training levels, lack of targeted contents, neglect of skill training and process management, and absence of quality assessment of training processes and effects. Conclusion The training modes require that: a) specific plans and schemes; b) unified organization to integrate educational resources effectively; c) reasonable arrangement of implementation process, and d) innovation of training methods and contents to fully play the role of general hospitals and universities; and well control and feedback to promote the integration and perfection of training modes.