ObjectiveTo discuss the main auxiliary inspection methods and their guiding significance for inguinal hernia.MethodsBy searching literatures and international guidelines, to review the main auxiliary examination methods, such as ultrasound, CT, and MRI.ResultsClinical physical examination combined with ultrasound could increase diagnostic sensitivity. CT could provide surgeons with a better sense of wholeness and structural details, and could be used as a guide for specific types of inguinal hernia. The soft tissue recognition of MRI was good, and it had a good effect on the identification of hidden hernia, mesh conditions, and tissue inflammation.ConclusionEach examination has its own advantages, and should be selected based on clinical practice and medical center conditions.
ObjectiveTo summarize the research progress of patient-derived organoid (PDO) and patient-derived xenograft (PDX) models in preclinical drug screening for gastric cancer, aiming to provide a new perspective for precise drug screening and promote the application of personalized medicine and precision medicine for gastric cancer. MethodA literature review was conducted on the use of PDO and PDX models in the basic research and preclinical drug screening for gastric cancer. ResultsThe PDO and PDX models of gastric cancer exhibited a higher tumor biological simulation capability and a relatively accurate preclinical drug response prediction. However, they each have some certain limitations. The advent of organoid models based on xenografting, which combines the advantages of both, is expected to compensate for their respective shortcomings. These models can better reflect the heterogeneity of patients’ tumors and have unique advantages in the evaluation of new targeted drugs for specific molecular targets in gastric cancer, such as epidermal growth factor receptor. They show a certain correlation with the actual clinical response of patients, paving a new way for the development of new drugs, the study of drug action and resistance mechanisms, and personalized therapy. ConclusionsPDO and PDX models, as a highly promising research platform, show a great potential in the screening of anti-tumor drugs and the development of personalized medical strategies.