ObjectiveTo evaluate the feasibility and security of endovascular repair of abdominal aorta using branched stent graft in a novel in vitro vascular model. MethodsThe branched stent graft for the abdominal aorta was designed. The novel in vitro vascular model was established to test this stent graft. Attempts were made to optimize the procedure of stent graft and to evaluate the feasibility of this device. The branched stent graft for abdominal aorta was tested by a novel in vitro vascular model. The number of stent graft released and expanded was recorded respectively. The pressure and situation of branch vessels were assessed before and after stent graft released. The endoleak during releasing process was observed by digital subtraction angiography (DSA). ResultsThe stent graft was successfully deployed in the novel in vitro vascular model. The releasing process was all properly achieved (100%, 30/30). The pressure changes of branch vessels were no statistical significances (P > 0.05) between before and after stent graft released. The stent grafts were well landed, and were fully expanded and properly positioned by DSA. No endoleak occurred. ConclusionThe branched stent graft for abdominal aorta in a novel in vitro vascular model is safe and feasible.
ObjectiveTo establish pig abdomen bullet wound model in seawater immersion condition and to analyze injury characteristics. MethodsTwenty Xishuangbanna pigs were randomly divided into seawater immersion group and control group,with 10 in each group.The left lower quadrant anti McBurney point of the pig semi-floating in the seawater was shot by using domestic 81-1 assault rifle at the distance of 10 meters,which were salvaged out of seawater at 60 minutes after injury in the seawater immersion group.The pigs in the control group were treated same as the seawater immersion group except seawater immersion.The mean arterial pressure (MAP),rectal temperature (RT),heart rate (HR),respiratory (R),white blood cell count (WBC),and C-reactive protein (CRP) were tested at 1 h,4 h,8 h after injury.The death of pig was observed. ResultsThe pig abdomen bullet wound models in the seawater immersion condition were successfully established.① Compared with the control group,the MAP and RT were significantly decreased at 1 h,4 h,8 h after injury,the HR or the R was significantly decreased at 4 h or 8 h after injury respectively in the seawater immersion group.② Compared with the normal value,the WBC obviously rose at 4 h and 8 h after injury,the CRP obviously rose at 1 h,4 h,and 8 h after injury in both two groups.Compared with the control group,the WBCs were significantly increased at 4 h and 8 h after injury (P<0.05),the CRPs were significantly increased at 1 h,4 h,and 8 h after injury (P<0.05) in the seawater immersion group.③ The mortality in the seawater immersion group (50%) was significantly higher than that in the control group (20%,P<0.05). ConclusionThe injury is more serious,the infection time is earlier,and the infection degree is aggravated,the mortality rate is higher for pig abdomen bullet wound model in seawater immersion condition.