Objective To analyze the influence of the ABO blood types of colorectal cancer patients served by West China Hospital as a regional center on surgical characteristics and postoperative complications in the current version of Database from Colorectal Cancer (DACCA). Methods The DACCA version was updated on January 5, 2022. The data items included ABO blood type, sex, type of operation, nature of operation and postoperative complications. The operative characteristics and complications at different stages after operation (in hospital, short-term and long-term after operation) of colorectal cancer patients with different blood types (A, B, AB, O) were analyzed. Results According to the DACCA database, we obtained 5 010 analysable data rows, covering 2005–2022. The results of blood types analysis showed that there was no significant difference among different blood types in the overall postoperative complications and the occurrence of complications in hospital, short-term and long-term after operation (P>0.05). Further subgroup analysis showed that only the difference of anastomotic leakage among different blood types was statistically significant (χ2=9.588, P=0.022). There was no significant difference among different blood types in whether the primary focus of colon cancer surgery was removed or not, the degree of radical resection of the primary focus, and whether the anus was preserved or not in rectal cancer surgery (P>0.05), and there was significant difference among different blood types with different degrees of radical resection of primary rectal cancer (χ2=15.773, P=0.001). Conclusions The ABO blood types of patients with colorectal cancer has nothing to do with the occurrence of overall complications in the short and long term after operation, and has no impact on the implementation of different surgical methods. However, the occurrence of a single postoperative anastomotic leakage is related to blood type, and its possible causes need to be further explored.
ObjectiveTo analyze the relation between ABO blood type and postoperative pathological features of patients with colorectal cancer served by West China Hospital of Sichuan University as a regional center in the current version of Database from Colorectal Cancer (DACCA). MethodsThe data of DACCA was updated on January 5, 2022. According to the screening conditions, the enrolled patients with colorectal cancer were divided into blood type A, B, AB, and O. The differences in the postoperative pathological characteristics of patients with different blood types, such as pathological TNM, T, N, M (pTNM, pT, pN, pM) staging, peripheral nerve involvement, high risk factors, tumor regression grade (TRG), and cancer nodules, were analyzed. ResultsAfter screening, 6 089 data rows were analyzed. The patients involved 2 058 blood type A, 1 469 blood type B, 494 blood type AB, and 2 068 blood type O. The results of statistical analysis showed that: ① There were statistical differences in the overall distribution of pTNM and pM stages among the patients with different blood types (H=11.564, P=0.009; H=7.947, P=0.047), which was reflected in: from the overall distribution trend, the proportion of patients with the four blood types in the same stage was similar, but it could still be seen that patients with blood type AB accounted for the highest proportion in the patients with stage Ⅲ, Ⅳ, M1a, M1b as compared with other blood types. ② There were no statistical differences in the overall distribution of peripheral nerve involvement and TRG in the patients with different blood types (H=3.414, P=0.332; H=1.143, P=0.767). ③ There was statistical difference in the proportion of different grades of high risk factors in the patients with different blood types (H=14.540, P=0.002). Specifically, the proportions of patients with grade 3–5 of high risk factors in the patients with AB blood type were the highest. ④ There was no statistical difference in the proportion of the grade of cancer nodules number in patients with different blood types (H=4.460, P=0.216). ConclusionsFrom results of this study, it is found that there are some differences in pTNM stage, pM stage, and high risk factors of colorectal cancer patients with different blood types, but no differences in pT stage, pN stage, peripheral nerve involvement, TRG, and cancer nodules among different blood types of patients. The influence of blood type on postoperative pathological characteristics of colorectal cancer patients needs to be further explored.