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find Author "WU Yuanchao" 1 results
  • Effect of Statins on Bone Mineral Density in the Elderly

    Objective To determine whether statins has some effects on the treatment of cardio-cerebral vascular diseases or hyperlipdemia increases bone mineral density (BMD). Methods One hundred and sixty-two patients aged over 60 were identified in the outpatient-department of Geriatrics of West China Hospital from Jan. 1998 to Aug. 2003. Seventy cases were exposed to statins with follow-up for 5 years. BMD of the spine, femoral neck, femoral wards triangle and femoral trochanter was measured by dual-energy X-ray absorptiometry. The multiple regression analysis was used to exclude potential confounders, e.g. age, BMI, comorbidity,etc. Results Those elderly patients with a history of taking statins had higher BMD, such as femoral neck with t =-2. 466 (P =0. 015), femoral wards triangle with t =-2. 483 (P = 0. 014 )and femoral trochanter with t =-2. 743 (P =0. 007 )than the control elderly at the end of follow-up. Conclusions It has been found that HMG-CoA reductase inhibitors (statins ) may prevent bone loss in elderly patients by increasing BMD. Further prospective studies of statins are needed to confirm these observatioris.

    Release date:2016-08-25 03:34 Export PDF Favorites Scan
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