ObjectiveTo analyze the clinical characteristics and geographical distribution of Keshan disease in Chongqing city for prevention and disease control. MethodsWe collected the clinical data of patients with Keshan disease from 2008 to 2012 in Liangping, Shizhu, Fengdu and Dianjiang counties as well as Wanzhou district of Chongqing city including the medical history, physical examination, results of laboratory tests to analyze the clinical characteristics and geographical distribution. ResultsFifty-eight patients were included from Liangping (n=21), Shizhu (n=25), Fengdu (n=11) and Dianjiang (n=1). The number of patients with potential and chronic Keshan disease was 16 and 42, respectively. The average age of patients was 54.91±15.53 years. The proportion above age 60 was 32.76% and below age 10 was 3.45%. The patients had main clinical signs as heart enlargement (36.76%), low-weak first heart sound (22.41%), systolic murmur (10.34%), arrhythmia (8.62%), etc. Abnormal ECG detection rate was 98.28%, with common types followed by sinus rhythm (37.93%), complete right bundle branch block (25.86%), ST-T changes (24.14%), left ventricular hypertrophy (15.52%), atrial fibrillation (13.79%), occasional ventricular premature (10.34%), T changes (10.34%), sinus bradycardia (8.62%), and incomplete right bundle branch block (6.90%). X-ray results showed that heart enlargement accounted for 82.76%. The ratios of mild, moderate and significant expansion of the heart were 46.55%, 27.59%, and 8.62%, respectively. ConclusionIn recent years, most patients with Keshan disease in Chongqing are chronic type at older age. The main clinical symptom is heart enlargement with high abnormal ECG detection rate.
ObjectiveTo understand the prevention and control effects of iodine deficiency disorders and its progression trend of disease condition in Chongqing. MethodsOne primary school was randomly selected as longitudinal surveillance sites in each of 4 counties in Chongqing city. A total of 90 children aged 8 to 10 years were randomly selected in each school with goiter, salt iodine, urinary iodine and intelligence detected. Meanwhile, in the four sites, urinary iodine of pregnant women and nursing women was tested. The goiter was examined by B-ultrasonograghy, urinary iodine by Ce arsenic acid digestion, and salt iodine by direct drop methods. ResultsA total of 360 children aged 8 to 10 years were investigated surveillance sites. The total goiter rate was 5.28%. There was no significant difference in the total goiter rate among different counties (P > 0.05). The median of iodized salt was 26.65 mg/kg. The coverage rate of iodized salt, consumption rate of qualified iodized salt and intake rate of qualified iodized salt was 99.72%, 91.09% and 97.04%, respectively. The medians of urine iodine of children, pregnant and nursing women were 238.15 μg/L, 218.15 μg/L and 252.90 μg/L, respectively. The cases with urine iodine lower than 100 μg/L accounted for 11.94%, 32.93% and 13.75%, respectively. The cases with urine iodine above 300 μg/L accounted for 34.17%, 13.41% and 43.75%, respectively. The mean intelligence quotient of children was 112.57. ConclusionThe goiter rate of schoolchildren in Chongqing city is relatively high and the population's iodine nutrition level is stable. However, the shortage and overdose of iodine still exist in Chongqing city.