Objective To summarize the advance of bioenergetic metabolic mechanisms of cancer cell. Methods Literatures about the recent studies on the bioenergetic metabolic mechanisms of cancer cell were reviewed.Results Cancer cells required a steady source of metabolic energy in order to continue their uncontrolled growth and proliferation. Accelerated uptake of glucose and glycolysis was one of the biochemical characteristics of hypoxia cancer cells. Glucose transport and metabolism were essential for the survival of tumor cells, leading to poor prognosis. Conclusions The studies on relationships between hypoxia-inducible genes and cancer have come a new understanding of the bioenergetic metabolic mechanisms of cancer cell, become new and important supplementary means of diagnosis and treatment of cancer, and enhanced existing strategies so that the treatment could be more rationally applied and personalized for cancer patients.
ObjectiveTo summarize the research progress of bioenergetic metabolic mechanisms regulated of tumor cells by microRNA in recent years. MethodsLiteratures about the recent studies on the bioenergetic metabolic mechanisms regulated of tumor cells by microRNA were reviewed according to the results searched from PUBMED. ResultsAerobic glycolysis(Warburg effect) is the most significant characteristics of bioenergetic metabolism in tumor cells. MicroRNAs can regulate many key progressions involved in tumor cells bioenergetic metabolism, such as uptake of glucose, glycolytic pathway, tricarboxylic acid cycle(TAC), and the relationship among lipid metabolism, amino acid metabolism and TAC, resulting in accelerated uptake of glucose and glycolysis. Thus we believe that the transportation and metabolic procession are vital important for tumor cells and related to poor prognosis of patients. ConclusionsThe studies on relationship between microRNA and bioenergetic metabolism have come an important insight for malignant biological behavior of tumor cells based on abnormal bioenergetic metabolism and also become new and important supplementary means of diagnosis and treatment of cancer. As far as the research progress about tumor cells bioenergetic metabolism regulated by microRNA, one of the things must be revealed is that which metablic factors can directly change tumor biological behavior after tumor cells bioenergetic metabolism changed caused by microRNA.
ObjectiveTo summarize the latest research advance of monocarboxylate transporter proteins in malignant tumors in recent years. MethodsLiteratures about the recent studies on the regulation of monocarboxylate transporter proteins and the regulation of bioenergetic metabolic mechanisms in malignant tumors were reviewed according to the literatures searched from domestic and foreign databases. ResultsThe abnormal high expression of the monocarboxylate transporter proteins existed in most of tumor cells' membrane, which endowed tumor cells high glycolysis rate and acid resistant phenotype, providing theoretical proofs for study of malignant biological behavior and therapeutic target of cancer cells. ConclusionsThe studies about the regulation of monocarboxylate transporter proteins on tumors' microenvironment and bioenergetic metabolism provide important clues for solving the mechanism of malignant biological behavior of tumor cells which based on abnormal bioenergetic metabolism. in this point, they also provide an opportunity for cancer treatment and are likely to become a new hotspot in cancer treatment.
Objective To summarize the latest research progress of tumor energy metabolism regulated by long non-coding RNA (lncRNA). Method Literatures about the recent studies on the bioenergetic metabolic mechanisms regulated by lncRNA in tumor cells were reviewed according to the results searched from PubMed database, Springer database, HighWire database, and so on. Results Aerobic glycolysis (Warburg effect) was regarded as the most important characteristics of energy metabolism in tumor cells. lncRNA could regulate many key progressions involved energy metabolism in tumor cells, such as glucose metabolism, lipid metabolism, and glutamine metabolism, resulting in accelerated uptake of glucose, decomposition of glutamine, and formation of lipid. Conclusions The functions and mechanisms of energy metabolism in tumor cells regulated by lncRNA are entirely unclear. The role of lncRNA played in cancer needs to be understood, which may contribute to new tumor biomarker detection and effective treatment strategies.
Objective To summarize progress of Warburg effect in colorectal cancer and to provide basis for diagnosis and treatment of colorectal cancer. Method The relevant literatures about the Warburg effect in the colorectal cancer in recent years were reviewed. Results The Warburg effect played a significant role in the growth, proliferation, and metastasis of the colorectal cancer cells. It was contributed to the growth of cancer cells and inhibited the apoptosis, at the same time it created the suitable environmental conditions for the tumor metastasis. Conclusions Mechanism of Warburg effec in occurrence and development of colorect cancer is not unclear. Warburg effect and relationship between its key enzyme (hexokinase, phosphofructokinase, and pyruvate kinase) and colorectal caner need to be studied so as to providing a new direction and approach for early diagnosis and treatment of colorectal cancer.