ObjectiveTo explore the therapeutic value of ultrasound-guided minimally invasive Mammotome system for mammary glands nodules without type-B ultrasound echo. MethodsBetween May 2009 and April 2014, 95 patients with mammary glands nodules without type-B ultrasound echo accepted B-ultrasound guided mammotome rotary cutter excision. ResultsPreoperative B ultrasound showed single shot without echo in 30 cases and multiple shot without echo in 65 cases. Among the 95 cases without echo, there were 23 cases of mixed echo nodules, and 25 cases of clustered echo-free nodules. The postoperative pathological diagnosis showed non-proliferative fibrocystic changes in 78 cases, proliferative fibrocystic changes in 17 cases (including 1 case of carcinoma in situ), and 3 cases of intraductal papilloma. ConclusionUltrasound-guided minimally invasive Mammotome system is a choice for treating mammary glands nodules without type-B ultrasound echo.