循环纤维细胞是一类外周血中骨髓来源的间充质祖细胞, 其细胞表面表达造血细胞、单核细胞和成纤维细胞系的三种细胞标记, 参与组织应对损伤和破坏后的反应。根据近年来大量动物实验的研究, 循环纤维细胞的分化、迁移以及功能提示其在以慢性炎症和大量胶原沉积为特征的疾病中起着重要作用。尽管这些细胞参与疾病发生发展的具体机制仍然不清楚, 但是近年来积累的临床资料表明循环纤维细胞计数可以作为慢性肺部疾病( 包括肺纤维化、哮喘) 进展的生物学标志。通过免疫调节来影响循环纤维细胞的分化、迁移以及功能, 进而改善慢性炎症并减少胶原沉积, 可能成为治疗慢性肺部疾病特别是肺纤维化研究的新方向。
As a common disease in orthopedics, osteonecrosis of the femoral head (ONFH) frequently occurs among young and middle-aged people. Hip joint preserving surgery has attracted more and more attention due to the fact that artificial joint prosthesis has a certain useful life and the rate of hip joint revision is high and the higher risk of many complications. There are a large number of operative methods for preserving hip joint in clinical practice without definitive effectiveness. How to choose appropriate surgical methods at the right time is also a continuous understanding. The pathological process of necrosis of the femur helps to choose the choice of the femoral head necrosis for the treatment of hip operation. Core decompression and impaction bone grafting with simple operative methods can relieve internal pressure of femoral head and pain symptoms, but they cannot remove necrotic bone completely. Hence, they are only used for ONFH in the early stage. Vascularized bone transplantation can fill defects of the former, as it can not only completely remove necrotic bone, but also provide bone graft with nourishing vessels for femoral head, being beneficial to reconstruct the bone structure of femoral head. Subsequently, the application of tantalum rod can provide mechanical support for femoral head to prevent the collapse of femoral head. Hip joint preserving surgery, in recent years, has been performed increasingly, and has obtained improvement in clinical effects. The multiple combination of a variety of its operative methods provides more effective treatments for ONFH. It is an essential notion that hip joint preserving surgery, however with any operative method, should as far as possible select a surgical plan with little trauma, simple methods, and little injury of hip joint bone structure based on ensuring the effectiveness.