At present, there are relatively many clinical gene studies. microRNA -215 (miR-215) is a miRNA induced by p53. It exists in animals and humans. miR-215 can exist not only in tumor tissues, but also in blood, urine and feces. miR-215 is abnormally expressed in a variety of tumors and plays a role in promoting and inhibiting cancer. Therefore, miR-215 may provide a new research direction for tumor diagnosis, treatment and prognosis. This paper reviews the expression of miR-215 as a oncogene and tumor suppressor gene in tumors and in non tumors.
Objective To summarize clinical application status of auxiliary heterotopic liver transplantation. Methods Reviewed relevant literatures and made a summary. Indications, contraindications, surgical treatment, therapeutic efficacy, and existing problems of auxiliary heterotopic liver transplantation were summed up. Results Main indication of auxiliary heterotopic liver transplantation is fulminant liver failure, and with no absolute contraindications. Partial liver transplantation is more popular. The therapeutic efficacy of auxiliary heterotopic liver transplantation is confirmed, but there are still some problems needed to be solved. Conclusion Auxiliary heterotopic liver transplantation is an effective method and replacement therapy for acute and chronic liver failure.