ObjectiveTo review the research progress of C5 palsy (C5P) after cervical surgery, providing new clinical intervention ideas for the C5P patients. MethodsThe relevant literature domestically and abroad was extensively consulted and the latest developments in the incidence, risk factors, manifestations and diagnosis, prevention, and intervention measures of C5P were systematically expounded. ResultsC5P is characterized by weakness in the C5 nerve innervation area after cervical decompression surgery, manifested as limited shoulder abduction and elbow flexion, with an incidence rate more than 5%, often caused by segmental spinal cord injury or mechanical injury to the nerve roots. For patients with risk factors, careful operation and preventive measures can reduce the incidence of C5P. Most of the patients can recover with conservative treatment such as drug therapy and physical therapy, while those without significant improvement after 6 months of treatment may require surgical intervention such as foraminal decompression and nerve displacement. ConclusionCurrently, there has been some advancement in the etiology and intervention of C5P. Nevertheless, further research is imperative to assess the timing of intervention and surgical protocol.