目的 探讨3D-多体素磁共振波谱（MRS）在评估脑胶质瘤手术切除程度的价值。 方法 对2011年6月－2012年4月32例脑胶质瘤患者术后行常规MRI及MRS检查，测定分析手术周边区域主要代谢产物N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、肌酸（Cr）、Cho/NAA、Cho/Cr及NAA/Cr比值，对术后胶质瘤切除程度进行评价。同时通过术后病理检查结果评估肿瘤切除程度，再与MRS评估结果相比较。 结果 32例中病理评估为9例全切除，23例为大部分切除；MRS评估为11例全切除，21例为大部分切除，评估结果与术后病理评估结果差异无统计学意义（P＞0.05）。 结论 MRS可以无创评价胶质瘤切除程度，为胶质瘤预后判定及进一步治疗提供了重要的依据。
Objective To investigate the application of the dynamic contrast enhanced MRI (DCE-MRI ) combined with magnetic resonance spectroscopy (MRS) in the diagnosis of prostate cancer. Method A total of 60 patients with prostate cancer and 60 patients with benign prostatic hyperplasia diagnoses in Sichuan Cancer Hospital from January 2011 to January 2014 were included as prostate cancer group and proliferative group respectively. Sixty healthy individuals during the same period were included as the control group. We used Siemens Avanto 1.5 T high field superconducting MRI for DCE-MRI scan and MRS scan. After the MRS scan was finished, we used the workstation spectroscopy tab spectral analysis. Eventually we got the crest lines of prostate metabolites choline (Cho), creatine (Cr) and citrate (Cit). Then we calculated Cho/Cit, (Cho+Cr)/Cit and their average. Results Comparing the signal value in 21 seconds, 1 minute, 2 minutes of DCE-MRI, the differences among the three groups were statistically significant (P<0.05). Comparing the results of spectral analysis, the differences among the three groups were statistically significant (P<0.05). The sensitivity was 89.67%, the specificity was 95.45% and the accuracy was 94.34% when using DCE-MRI combined with MRS. Conclusion DCE-MRI combined with MRS greatly improves the sensitivity, specificity and accuracy of the diagnosis of prostate cancer; it has a great application value in the diagnosis of prostate cancer.