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find Author "XU Yuxia" 2 results
  • Correlation between Serum Lipid Metabolism and Coronary Artery Pathology in Children with Kawasaki Disease

    目的 探讨川崎病(Kawasaki disease,KD)患儿血脂代谢与冠状动脉病变之间的关系。 方法 纳入2007年1月-2009年10月住院治疗的82例KD患儿,检测治疗前后血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、极低密度脂蛋白(VLDL-C)、载脂蛋白A1(ApoA1)及载脂蛋白B100(ApoB100)水平。选取50例健康儿童作为对照。KD患儿在治疗前行超声心动图检查,根据超声心动图显示将KD组再分为冠状动脉病变组(CAL组,n=31)和非冠状动脉病变组(NCAL,n=51)。 结果 治疗前,KD患儿TC、ApoA1、HDLC降低,TG、LDL-C升高,与正常儿童相比有统计学意义(Plt;0.05)。KD患儿CAL组较NCAL组变化更明显,有统计学意义(Plt;0.05)。VLDL-C和ApoB100水平KD患儿与正常儿童比较、NCAL组与CAL组比较变化均不明显(Pgt;0.05)。治疗后与治疗前相比,NCAL组TC、TG、HDL-C、LDL-C、ApoA1恢复正常(Plt;0.05)),而CAL组仅TC、LDL-C、ApoA1恢复正常(Plt;0.05)。 结论 KD患儿存在血脂代谢紊乱,TC、TG、HDL-C、LDL-C、ApoA1与冠状动脉的损害有关,应早期进行干预。

    Release date:2016-09-08 09:49 Export PDF Favorites Scan
  • Analysis on Clinical Characteristics of Infectious Mononucleosis in Children

    【摘要】 目的 探讨儿童传染性单核细胞增多症(IM)的临床特点。 方法 回顾性分析2005年8月-2009年8月收治的151例IM患儿的症状、体征、实验室检查及治疗效果。 结果 IM临床表现以发热、咽峡炎、肝脾和淋巴结肿大最常见,鼻塞、眼睑浮肿也是重要体征。外周血出现异型淋巴细胞及EBV-IgM抗体检测可帮助确诊。更昔洛韦治疗IM效果确切。 结论 应重视IM临床特点,有助于早期诊断并提高确诊率,应用更昔洛韦治疗值得推广。【Abstract】 Objective To investigate the clinical features of infectious mononucleosis (IM) in children. Methods A total of 151 children with infectious mononucleosis admitted from August 2005 to August 2009 were reviewed. The symptoms, signs, laboratory tests, and treatment of infectious mononucleosis were analyzed. Results Fever, angina, hepatomegaly, splenomegaly, and swollen lymph nodes were the most common clinical manifestations of IM. Nasal congestion and eyelid edema were also two important signs. Atypical lymphocytes in peripheral blood and EBV antibody (VCA-IgM) could help confirm the diagnosis. The antiviral treatment with ganciclovir was effective for infectious mononucleosis. Conclusion Clinical features of infectious mononucleosis are helpful to the diagnosis. Treatment with ganciclovir should be promoted.

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