Energy interruption and infrastructure damage are the common characteristic between the snow disaster occurred in some southern provinces of China and the 5?12 Wenchuan earthquake in China in 2008. This paper summaries the effects on medical and health institutions caused by interruption of energy flow and damaged infrastructure, shares the preparation and response practices, experience, and lessons of medical disasters, and gives suggestions about how to prepare and response for medical and health institutions when energy flow is interrupted and infrastructure is damaged.