Objective To know the basic research and the clinical application of cartilage-derived retinoic acid-sensitive protein (CD-RAP) in orthopedic and in other clinical fields. Methods The literature related to CD-RAP in basic research and clinical application were extensively reviewed. Results CD-RAP, as a protein, which is cartilage-specific,could be a marker of the joint diseases. It also can be used to monitor metastsais of melanoma. Conclusion CD-RAP test provides a new way to study repair of cartilage and metastsais of melanoma.
【Abstract】 Objective To investigate the relationships between residual displacement of weight-bearing and non weight-bearing zones (gap displacement and step displacement) and hip function by analyzing the CT images after reconstruction of acetabular fractures. Methods The CT measures and clinical outcome were retrospectively analyzed from 48 patients with displaced acetabular fracture between June 2004 and June 2009. All patients were treated by open reduction and internal fixation, and were followed up 24 to 72 months (mean, 36 months); all fractures healed after operation. The residual displacement involved the weight-bearing zone in 30 cases (weight-bearing group), and involved the non weight-bearing zone in 18 cases (non weight-bearing group). The clinical outcomes were evaluated by Merle d’Aubigné-Postel criteria, and the reduction of articular surface by CT images, including the maximums of two indexes (gap displacement and step displacement). All the data were analyzed in accordance with the Spearman rank correlation coefficient analysis. Results There was b negative correlation between the hip function and the residual displacement values in weight-bearing group (rs= — 0.722, P=0.001). But there was no correlation between the hip function and the residual displacement values in non weight-bearing group (rs=0.481, P=0.059). The results of clinical follow-up were similar to the correlation analysis results. In weight-bearing group, the hip function had b negative correlation with step displacement (rs= — 0.825, P=0.002), but it had no correlation with gap displacement (rs=0.577, P=0.134). Conclusion In patients with acetabular fracture, the hip function has correlation not only with the extent of the residual displacement but also with the location of the residual displacement, so the residual displacement of weight-bearing zone is a key factor to affect the hip function. In patients with residual displacement in weight-bearing zone, the bigger the step displacement is, the worse the hip function is.
目的 评价股骨近端防旋髓内钉（PFNA）、动力髋螺钉（DHS）、伽马钉治疗股骨转子间骨折的有效性和安全性。 方法 计算机检索Cochrane图书馆（2011年第12期），PubMed （1966年－2011年12月），EMBASE（1974年－2011年12月），web of science（1958年－2011年12月），万方数据库（1992年－2011年12月），维普资讯网（1989年－2011年12月），中国期刊全文数据库（1994年－2011年12月），中国生物医学文献数据库（1978年－2011年12月），纳入PFNA、DHS、伽马钉治疗股骨转子间骨折的随机前瞻性研究，采取修订后的Jadad评分量表对纳入研究进行质量评价。用RevMan 5.1软件进行Meta分析。 结果 共纳入12个研究（1 477例患者）。Meta分析结果显示PFNA治疗股骨转子间骨折的手术时间[MD=−32.19，95%CI（−49.69，−14.69），P=0.000 3；MD=−4.52，95%CI（−5.24，−3.80），P＜0.000 01］，出血量[MD=−183.06，95%CI（−277.37，−88.74），P=0.000 1；MD=−49.49，95%CI（−84.15，−14.83），P=0.005]少于DHS组和伽马钉组，但是三者在总有效率、住院时间和术后并发症等方面差异无统计学意义。DHS组与伽马钉组在所有指标差异均无统计学意义。 结论 与DHS、伽马钉相比，PFNA可明显缩短手术时间、降低术中出血量，但并不能提高总有效率、缩短住院时间以及减少术后并发症；而DHS与伽马钉治疗股骨转子间骨折的疗效无明显差异。