【摘要】 目的 研究ΔNP63/TAP63在上皮性卵巢肿瘤组织中的表达及其与临床病理特征的关系。 方法 运用荧光定量聚合酶链反应方法检测2002年-2004年54例卵巢上皮性肿瘤中ΔNP63/TAP63的基因水平。 结果 33例卵巢上皮细胞癌组织中ΔNP63的表达高于21例良性上皮性肿瘤中组织。卵巢上皮细胞癌中的表达强度与肿瘤组织病理学分期相关（Plt;0.05），良性肿瘤的表达低于恶性肿瘤（Plt;0.05）。ΔNP63的表达高于TAP63（Plt;0.05）；各组间TAP63的表达差异无统计学意义（Pgt;0.05）。 结论 ΔNP63在上皮性卵巢癌中高表达，可能成为上皮性卵巢癌诊断及预后的分子标志物。【Abstract】 Objective To explore the expression of ΔNP63 / TAP63 in human epithelial ovarian tumor tissues and its relationship with the clinicopathological features. Methods Fluorescent quantitative PCR method was used to detect 54 cases of ΔNP63 / TAP63 gene level in 54 patients with epithelial ovarian tumors diagnosed between 2002 and 2004. Results ΔNP63 expression in the 33 cases of ovarian epithelial cell carcinoma was higher than that in the 21 cases of benign epithelial tumor tissue. The expression in ovarian epithelial cell carcinoma was concerned with the pathological staging of tumor (Plt;0.05); the expression in benign tumors was lower than that in the malignant tumors (Plt;0.05). In all cases, the expression of ΔNP63 was higher than that of TAP63 (Plt;0.05); the difference in the expression of TAP63 among the groups was not significant (Pgt;0.05). Conclusion ΔNP63 in epithelial ovarian cancer is highly expressed, which may become the molecular makers with diagnosis and prognosis of epithelial ovarian cancer diagnosis in the future.