Objective To provide evidence for the establishment and improvement of public health system in China by comparing national public health emergency system of some representative countries.Methods The principle and method of evidence-based science were applied to search and evaluate data from the official websites of China, United States, United Kingdom, Australia and Singapore. The performance of each country’s public health emergency response system in SARS prevention and control, as well as their organization structure and mechanism were compared. The existing problems and corresponding countermeasures were then put forward. Results Public health system showed the best performance was in US, UK and Australia. The responding mechanism of Singapore was highly admired by WHO. The organization structure of China was similar to that of developed countries, but its performance was far lagged behind because of insufficient financial support, poor management and inefficient operational mechanism. Conclusions The public health emergency response system in China needs to be reformed by giving priority to mechanism reinforcement. Different models should be taken into account regarding different regional situations in China.