目的:探讨开颅夹闭和血管内栓塞治疗颅内动脉瘤的效果比较及并发症。方法:从2003～2008年近五年来我院收治的颅内动脉瘤54例,其中开颅夹闭24例(Hunt Hess分级Ⅰ～Ⅱ级20例,Ⅲ级2例,Ⅳ级2例),共26个动脉瘤。血管内栓塞30例(HuntHess分级Ⅰ～Ⅱ级23例,Ⅲ级5例,Ⅳ级2例),共31个动脉瘤。临床结果按GOS进行评价。结果:两组的良好率、并发症及死亡率无显著差别(Pgt;0.05)。随访平均12月,Ⅰ～Ⅱ级动脉瘤患者治疗良好率为100.0％(43/43),并发症发生率为4.7％(2/43),Ⅲ～Ⅳ级者分别为18.2％(2/11)和90.9％(10/11),两者相差显著(Plt;0.05)。结论:开颅夹闭和血管内栓塞治疗颅内动脉瘤,二者疗效相仿,各有优缺点。动脉瘤患者病情级别越高,治疗效果越差。
Objective To explore the microRNA （miRNA） expression changes and related miRNA characteristics of colorectal cancer （CRC） with hepatic metastasis by miRNA microarray. Methods The fresh specimens of primary CRC were collected in 10 patients during operation， which with hepatic metastasis or not. miRNA microarray analysis was performed to compare the miRNA expression levels in two groups. The different expression levels of miRNA were validated by quantitative real-time PCR analysis. Results A total of six dysregulated miRNAs were identified in the CRC patients with hepatic metastasis comparing with CRC patients without hepatic metastasis， including 3 up-regulated miRNAs （miR-224， miR-1236， and miR-622） and 3 down-regulated miRNAs （miR-155， miR-342-5p， and miR-363）， and the quantitative real-time PCR result of miR-224 consisted with the microarray finding. Conclusions miR-224 may be involved in the process of CRC with hepatic metastasis pathogenesis. miR-224 would be a research direction on a new biomarker or therapic method in CRC with hepatic metastasis.