Objective To observe the life quality and the immune function of colorectal cancer patients treated by huaier granule combined with FOLFOX4 chemotherapy. Methods A total of 76 cases of colorectal cancer with chemotherapy indications were divided into two groups at random. Huaier granule and FOLFOX4 chemotherapy was applied in trial group, meanwhile, placebo and FOLFOX4 chemotherapy in control group. The changes of life quality, common condition, and immune state in two groups before and after treatment were abserved. Results The effective rate in the trial group was 92.1% (35/38), and in the control group was 65.8% (25/38), χ2=7.91, P<0.005. The life quality improving rate in the trial group was 78.9% (30/38), and in the control group was 31.6% (12/38), χ2=6.33, P<0.05. The CD3 increase rate in the trial group was 65.8%(25/38), and in the control group was 23.7 % (9/38), χ2=7.96, P<0.005, the CD4/CD8 increase rate in the trial group was 68.4 %(26/38) , and in the control group was 28.9% (11/38), χ2=10.53, P<0.005. Conclusions Huaier granule can significantly improv the clinical symptoms, life quality, and immune state. Huaier granule combined with FOLFOX4 chemotherapy is a new effective scheme to cure colorectal cancer, is worth further generalization.