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find Author "Yuezhong ZHENG Jichuan SHI" 3 results
  • 葡萄膜炎的生物治疗进展

    葡萄膜炎的发生与CD4+T细胞介导的自身免疫功能异常有关,糖皮质激素和免疫抑制剂是治疗葡萄膜炎的主要药物,这些药物有着严重的毒副作用。利用单克隆抗体等生物制剂拮抗或封闭与疾病相关的淋巴细胞、细胞因子或细胞因子受体,可以达到治疗葡萄膜炎的目的。这类生物制剂主要包括抗肿瘤坏死因子制剂、干扰素、白细胞介素受体拮抗剂、细胞毒T细胞相关抗原-4融合蛋白和CD20嵌合性单克隆抗体。生物治疗为顽固性葡萄膜炎患者的治疗带来了希望,但是临床观察病例数较少,缺乏随机化临床试验,这些制剂的适应证、治疗剂量和治疗时间均有待于进一步观察。

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
  • Measurement and significance of serum interferon-γ, tumor necrosis factor-α and interleukin-6 in patients with uveitis

    Objective To examine the levels of interferon-gamma; (INF-gamma;), tumor necrosis factor-alpha; (TNF-alpha;) and interleukin-6(IL-6) in serum of patients with acute uveitis before and after treatment, and to explore the possible roles of those cytokines in the initiation and progression of the uveitis. Methods A series of 75 patients with acute uveitis,and 30 healthy persons from our hospital were investigated. The levels of INF-gamma;, TNF-alpha; and IL-6 in acute phase and convalescent phase were measured by the enzymelinked immunosorbent assay. Result The serum levels of INF-gamma;, TNF-alpha; and IL-6 in acute phase were significantly higher than that of the convalescent phase and the healthy controls (F=65.805/50.418/155.381, P=0.000). A significant negative correlation was found between the serum levels of INF-gamma;, TNF-alpha; and IL-6 in acute phase with their initial visual acuity(r=-0.656, -0.592 and -0.653, Plt;0.01). There was also a positive correlation among the serum levels of INF-gamma;, TNF-alpha; and IL-6(r=0.340, 0.467 and 0.338, Plt;0.05). Conclusions There are high serum levels of INF-gamma;, TNF-alpha; and IL-6 in patients with acute uveitis, and the cytokines levels were decreased after the treatment. The results suggested that the INF-gamma;, TNF-alpha; and IL-6 involved in initiation and progression of uveitis. 

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
  • Clinical features and treatment of intermediate uveitis

    Objective To observe the clinical features, the complications and treatment effects of intermediate uveitis. Methods The clinical data of 36 patients (66 eyes) with intermediate uveitis were retrospectively analyzed,including the clinical features, fundus fluorescein angiography (FFA) features, complications,treatment effects and prognosis. The patients, 21 males and 15 females, aged from 8 to 70 years,with the mean age of 34.8 years. There were 30 cases with bilateral lesions and 6 cases with unilateral lesions. Results The main clinical manifestation were vitreous opacity, peripheral retinal venous lesions, optic disc edema, macular edema and posterior subcapsular cataract. The results of FFA showed that peripheral retinal venous lesions, optic disc hyperfluorescence, cystoid macular edema and retinal vein staining. After the treatment, the visual acuity of 31 cases(60 eyes,90.9%) were improved, 4 cases(5 eyes,7.6%) were stable and 1 case(1 eye,1.5%) was worsening. The main complications were cystoid macular edema, posterior subcapsular cataract and vitreous hemorrhage which leads to visual damage. Conclusions Intermediate uveitis was a common bilateral and chronic progressive intraocular inflammation,the anterior vitritis, pars plana and peripheral retinal vascular changes were mainly involved. Early diagnosis and proper treatment may prevent the permanent visual damage. 

    Release date:2016-09-02 05:46 Export PDF Favorites Scan
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