【摘要】 目的 了解中药千里光对金黄色葡萄球菌的抗菌作用，为治疗金黄色葡萄球菌感染提供依据。 方法 将金黄色葡萄球菌在固体培养基上传代培养后收集菌株，以一定浓度（菌落浓度为 3亿/mL）用于腹腔注射。提取千里光水煎剂（2 g/mL）， 以其用于对小白鼠体内抗菌实验。 结果 灌胃千里光水煎剂的实验组死亡率显著降低。 结论 中药千里光对金黄色葡萄球菌有一定的抑制效果。【Abstract】 Objective To evaluate the antibacterial effect of traditional Chinese medicine Senecio against staphylococcus aureus, and to provide a experimental basis for the infectious treatment of staphylococcus aureus. Methods Staphylococcus aureus were cultured in solid medium and collected after uploading strains of a certain concentration (with the concentration of 300 million colonies/mL) for intraperitoneal injection. Senecio decoction extraction (2 g/mL) was used for mice in vivo antibacterial tests. Results The mortality rate in the experimental group with stomach perfusion of the Senecio water decoction decreased significantly. Conclusion The traditional Chinese medicine Senecio has a certain suppressive effect on staphylococcus aureus.
ObjectiveTo summarize the experience of minimally invasive anterior mediastinal tumor resection in our center, and compare the Da Vinci robotic and video-assisted thoracoscopic approaches in the treatment of mediastinal tumor.MethodsA retrospective cohort study was conducted to continuously enroll 102 patients who underwent minimally invasive mediastinal tumor resection between September 2014 and November 2019 by the single medical group in our department. They were divided into two groups: a robotic group (n=47, 23 males and 24 females, average age of 52 years) and a thoracoscopic group (n=55, 29 males and 26 females, average age of 53 years). The operation time, intraoperative blood loss, postoperative thoracic drainage volume, postoperative thoracic drainage time, postoperative hospital stay, hospitalization expense and other clinical data of two groups were compared and analyzed.ResultsAll the patients successfully completed the surgery and recovered from hospital, with no perioperative death. Myasthenia gravis occurred in 4 patients of the robotic group and 5 of the thoracoscopic group. The tumor size was 2.5 (0.8-8.7) cm in the robotic group and 3.0 (0.8-7.7) cm in the thoracoscopic group. Operation time was 62 (30-132) min in the robotic group and 60 (29-118) min in the thoracoscopic group. Intraoperative bleeding volume was 20 (2-50) mL in the robotic group and 20 (5-100) mL in the thoracoscopic group. The postoperative drainage volume was 240 (20-14 130) mL in the robotic group and 295 (20-1 070) mL in the thoracoscopic group. The postoperative drainage time was 2 (1-15) days in the robotic group and 2 (1-5) days in the thoracoscopic group. There was no significant difference between the two groups in the above parameters and postoperative complications (P>0.05). The postoperative hospital stay were 3 (2-18) days in the robotic group and 4 (2-14) in the thoracoscopic group (P=0.014). The hospitalization cost was 67 489(26 486-89 570) yuan in the robotic group and 27 917 (16 817-67 603) yuan in the thoracoscopic group (P=0.000).ConclusionCompared with the video-assisted thoracoscopic surgery, Da Vinci robot-assisted surgery owns the same efficacy and safety in the treatment of mediastinal tumor, with shorter postoperative hospital stay, but higher cost.