Pricing and investment of scientific and technological achievements is one of the important forms of achievement transformation. Due to its unique transformation mechanism advantages, it has become increasingly prominent in “industry-university-research” cooperative innovation, and this transformation form has gradually becomea focus of hospital achievement transformation. Based on the policies and relevant laws/regulations, from the aspects of scientific and technological achievements pricing and investment and its development history, the difference between pricing and investment and transfer/licensing, and common problems of pricing and investment practice, this paper analyzes and discusses the characteristics and the problems that may be encountered in the implementation process of pricing and investment of scientific and technological achievements. It aims to provide feasible basis and reference for the practice of pricing and investment in scientific and technological achievements in hospitals.