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find Author "ZHANG Shiyun" 1 results
  • Effect and Mechanism of Sleeve Gastrectomy for Type 2 Diabetes Mellitus in GK Rats

    Objective To explore the effect and mechanism of sleeve gastrectomy (SG) for type 2 diabetes mellitus (T2DM) in Goto-Kakizaki (GK) rats. Methods Thirteen male GK rats at 12 weeks of age were randomly divided into SG group (n=7) and sham operation group (SO group, n=6), receiving SG surgery and sham operation respectively.Body weight, food intake in 24hours, fasting plasma glucose, plasma glucagon-like peptide-1 (GLP-1), and plasma Ghrelin of rats in 2 groups were measured or tested before operation, 1, 4, 10, and 26 weeks after operation. In 10 weeks after operation, fecal energy content of rats in 2 groups was tested, in addition, oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were performed to investigate the glucose tolerance and insulin sensitivity. Results ①Body weight:there were no significant difference on body weight between the 2 groups (P>0.05). Compared with time point of before operation, the body weight of both 2 groups decreased in 1 week after operation (P<0.01), but increased in 10 weeks and 26 weeks (P<0.01). ②Food intake in 24 hours:compared with SO group, the food intake of SG group were lower in 4 weeks and 10 weeks after operation (P<0.05). Compared with time point of before operation, the food intake of SG group were lower in 1, 4, and 10 weeks after operation (P<0.05), but lower only in 1 week in SO group (P<0.05). ③Value of fasting glucose:compared with SO group, the value of fasting glucose in SG group were lower after operation (P<0.01). Compared with time point of before operation, the value of fasting glucose of SG group were lower after operation (P<0.01), but decreased in 1 week only in SO group (P<0.01). ④Level of serum GLP-1:compared with SO group, the levels of serum GLP-1 in SG group were higher in 4, 10, and 26 weeks after operation (P<0.05). Compared with time point of before operation, the levels of serum GLP-1 in SG group were higher in 4, 10, and 26 weeks after operation (P<0.05), but levels of serum GLP-1 in SO group didn’t change significantly (P>0.05). ⑤Level of serum Ghrelin:compared with SO group, the levels of serum Ghrelin in SG group were lower at alltime points after operation (P<0.01). Compared with time point of before operation, the levels of serum Ghrelin in SGgroup were lower at all time points after operation (P<0.001), but levels of serum Ghrelin in SO group didn’t change significantly (P>0.05). ⑥Areas under curves (AUC):the AUC of OGTT and ITT test in SG group were both lower than those of SO group (P<0.01). Conclusion SG surgery can induce the level of fasting plasma glucose, and canimprove glucose tolerance and insulin sensitivity with significant changes of levels of plasma GLP-1 and Ghrelin, sugg-esting that SG surgery may be a potential strategy to treat patient with T2DM but without obesity or insulin resistance.

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