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find Author "ZHANG Yong." 1 results
  • Expression of Beta-Catenin in Hilar Cholangiocarcinoma and Relevance to the Expression of c-myc Gene

    【Abstract】ObjectiveTo investigate whether abnormal expression of β-catenin and high expression of c-myc have played a possible role in hilar cholangiocarcinoma carcinogenesis.MethodsBy using immunohitochemical staining (SP method), the authors detected the expression of β-catenin and c-myc in 42 paraffin-embedded samples of hilar cholangiocarcinoma and 10 benign bile duct disease tissue, and then analyzed the relationship of them with clinical data. Resultsβ-catenin was normally expressed in 10 benign bile duct disease tissue, while expression of c-myc was negtive. In hilar cholangiocarcinoma tissue, the positive expression rate of β-catenin (71.4%) was significantly correlated to the lymphoid node metastasis of hilar cholangiocarcinoma (χ2=4.75,P<0.05),but was not statistically correlated to the tumor size,the extent of differentiation and infiltration (χ2=3.35,3.45,4.32,Pgt;0.05); the expression rate of c-myc (76.2%) was correlated with the extent of differentiation(χ2=4.87, P<0.05),but not with the size, infiltration, lymphoid metastasis(χ2= 3.47,4.12,2.76, Pgt;0.05). The abnormal expression of β-catenin had relevance to the high expression of c-myc with hilar cholangiocarcinoma (r=0.324,P<0.01). ConclusionThe expression of beta-catenin and c-myc is significantly altered in hilar cholangiocarcinoma, and correlate with biological features of cholangiocarcinoma.The abnormal expression of beta-catenin is one of the mechanisms for the spread of hilar cholangiocarcinoma.

    Release date:2016-08-28 04:30 Export PDF Favorites Scan
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