Objective To overview the systematic reviews about the efficacy and safety of respiratory fluoroquinolones for community-acquired pneumonia (CAP). Methods We electronically searched databases including China National Knowledge Internet, WanFang Data, VIP, PubMed, Embase and The Cochrane Library to collect systematic reviews or Meta-analyses about respiratory fluoroquinolones for CAP from inception to November 2, 2017. Two reviewers independently screened literatures, extracted data, and then AMSTAR tool was used to assess the methodological quality of included studies. Results A total of 18 systematic reviews/Meta-analyses were included. The results of quality assessment indicated the scores ranged from 5 to 10. Among the 11 items, the item 1 of " Was an ‘a priori’ design provided” and item 4 " Was the status of publication (i.e. grey literature) used as an inclusion criterion” appeared to be the most problematic. The results of overview suggested that: the efficacy of respiratory fluoroquinolones might be similar to β-lactams plus macrolides combination treatment for CAP. However, respiratory fluoroquinolones might be more safety. In addition, the efficacy of respiratory fluoroquinolones sequential therapy for CAP was similar to that of continuous intravenous therapy, but the adverse reactions of the former were fewer. Conclusions Respiratory fluoroquinolones might be similar in efficacy for CAP to other antibiotics recommended by the guidelines with less adverse reactions. However, it can increase multi-drug resistance and potential tuberculosis drug resistance, we should strictly follow the principle of rational use of antibiotics to avoid abuse.
Objective To overview the systematic reviews/meta-analyses of efficacy of FNB used as a postoperative analgesic technique among patients undergoing TKR. Methods We electronically searched databases including The Cochrane Library, PubMed, EMbase, CNKI, WanFang Data and VIP from inception to July, 2016. Two reviewers independently screened literature and extracted data. AMSTAR tool was used to assess the methodological quality of included studies. The primary outcome was pain scores and the consumption of opoid medicine to evaluate the effectiveness of FNB. Results A total of 16 systematic reviews/meta-analyses were included, involving the FNBvs. LIA, PMDI, EA, PCA and ACB, respectively. The results of quality assessment indicated medium scores with 3 to 9 scores. The overviews’ results showed that: at rest, FNB was not superior to LIA at 6h after TKR; it was superior to PMDI at 12h after TKR; it was also superior to PCA and LIA, but not superior to ACB at 24h after TKR. On movement, FNB was superior to PCA and LIA at 24h after TKR; it was also superior to PCA at 48h after TKR. As to the consumption of opoid medicine, the consumption in FNB group was more than LIA group at 12h after TKR. In addition, the consumption in FNB group was less than PCA and LIA at 24h after TKR, and it was also less than PCA and ACB at 48h. The satisfaction of patients who received FNB was better than ACB, EA and PCA. Conclusion The current overview shows that FNB is more effective than PCA and LIA, the patients’ satisfaction is better. Due to the limitations of the quantity and quality of included studies, the above conclusions are needed to be verified by more studies.
Objectives To overview the systematic reviews/meta-analyses of safety of femoral nerve block (FNB) used as a postoperative analgesic technique in patients undergoing total knee arthroplasty (TKA). Methods We searched databases including The Cochrane Library, PubMed, EMbase, CNKI, WanFang Data, and VIP from inception to July, 2016. Two reviewers independently screened literature, extracted data and used AMSTAR to evaluate the methodological quality of the included studies. The major indexes used to evaluate the safety of FNB were the incidence rates of symptoms including nausea, vomiting, sedation, retention of urine, dizziness, pruritus, hypotension, falls, nenous thromboembolism and deep infection. Results A total of 12 systematic reviews/meta-analyses were included.They assessed the safety of FNB compared with local infiltration analgesia (LIA), periarticular multimodal drug injection (PMDI), epidural analgesia (EA), patient-controlled intravenous analgesia of opioids (PCA) and adductor canal block (ACB), respectively. The methodological quality of included studies were medium, with the scores between 3 to 10. The results of overview indicated that: FNB had lower incidence rates of nausea and vomiting compared with EA and PCA, but had higher than ACB. FNB had lower incidence rates of sedation and retention of urine compared with EA and PCA. FNB had lower incidence rates of dizziness compared with EA and PCA, and lower incidence rate of hypotension compared with EA. Conclusion Current evidence suggests that FNB is safer than EA and PCA. Due to the limited quantity and quality of the included studies, the above conclusions are needed to be verified by more high-quality studies.
Objective To explore the characteristics of parenting styles of female patients with anorexia nervosa (AN) and bulimia nervosa (BN), to and provide a reference for the clinical treatment of eating disorders. Methods Patients with AN and BN between November 2019 and May 2020 in the Centre for Mental Health, West China Hospital, Sichuan University were retrospectively included. Female teachers and students from Sichuan University were used as normal controls. The general conditions of the subjects in the three groups were collected, and the parenting styles and behaviors of the subjects in the three groups were evaluated using Egna Minnen av Barndoms Uppfostran (Parenting Style Evaluation Scale). Results Finally, 30 subjects were included in the AN group, 44 subjects were included in the BN group, and 33 subjects were included in the healthy control group. There was no significant difference in the course of disease between the AN group and the BN group (P>0.05). There were no significant differences in age, place of residence, education level, parental divorce, parental education level and parental occupation among the three groups (P>0.05). The body mass index of the AN group was lower than that of the BN group and the healthy control group (P<0.05). The parenting style evaluation scale scores showed that in terms of father scores, there was no significant difference in the excessive interference dimension scores among the three groups (P>0.05). The score of preference dimension in AN group (14.60±4.45 vs. 10.18±5.98 vs. 10.36±5.90) was higher than that in BN group and healthy control group, the score of emotional warmth and understanding dimension in BN group (50.55±11.81 vs. 55.33±9.12 vs. 57.03±6.13) was lower than that in the AN group and the healthy control group, and the scores of rejection and denial dimension (7.91±3.65 vs. 10.10±3.85 vs. 10.16±3.83) and overprotection dimension (11.76±2.82 vs. 14.10±3.16 vs. 13.25±2.97) in healthy control group were lower than those of AN group and BN group (P<0.05). In terms of mother scores, the scores of preference dimension (14.40±4.64 vs. 10.59±5.92 vs. 10.94±5.34) in AN group was higher than that in the BN group and the healthy control group, and the scores of emotional warmth and understanding dimension (58.06±7.05 vs. 51.40±11.79 vs. 52.91±11.57) in healthy control group was higher than that in AN group and BN group (P<0.05). Conclusion Compared with healthy controls, the parenting styles of female patients with eating disorders show more negative emotions such as rejection and denial. The parenting styles of female BN patients show more negative emotions than female AN patients. These all suggest that the parenting style, attitude and behavior may be the influencing factors of female AN and BN.