ObjectiveTo evaluate the feasibility of susceptibility weighted imaging (SWI) in determining pathologic grade of hepatocellular carcinoma (HCC) in rat model. MethodsRat models were established first and SWI was performed before killing rats to be examined pathologically. The Edmondson-Steiner grading was used as gold reference for histological grade of HCC. The characters of intratumoral susceptibility signal intensity (ITSS) between lowand high-grade HCCs were compared. The diagnostic value of ITSS in differentiating lowfrom high-grade HCCs was evaluated. ResultsForty eight rat models of HCC were successfully established. Thirty two HCCs (18 low-grade HCCs and 14 highgrade HCCs) were included finally. The incidence of ITSS between two groups was not significant (P=0.113). Characters including component of ITSS (P=0.002) and ratio of ITSS in HCC (P < 0.001) were compared between lowand high-grade HCCs, which were both statistically significant. When score of ratio of ITSS in HCC was assessed as 2 scores, the sensitivity and specificity of ITSS in differentiating lowfrom high-grade HCCs were 85.7% (95% CI:74.9%-96.5%) and 94.4% (95% CI:83.6%-100%) respectively, and the area under roc curve (AUC) was 0.917. ConclusionSWI can evaluate characters of ITSS in HCC and can be an alternative method in grading HCC.
ObjectiveTo discuss application and research progress of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in liver and pancreas. MethodThe literatures about application and research progress of IVIM-DWI in liver and pancreas were researched and reviewed. ResultsWith the development of MRI, IVIM-DWI has become the hot research spot, and also has been widely used in liver and pancreas. It could make up the disadvantage of traditional DWI. IVIM-DWI holds an obvious value to assess the level of hepatic fibrosis or cirrhosis and differential diagnosis of liver tumors, diagnosis of pancreatic cancer and differential diagnosis of pancreatic cancers and mass type chronic pancreatitis. ConclusionIVIM-DWI has a great value in research of liver and pancreas, it is worth to be studied further.
ObjectiveTo summarize the application of dual-energy CT scanning technology in the liver. MethodsTo search the relevant literatures at home and abroad, then the application of dual-energy CT scanning technology in focal liver lesions, diffuse liver lesions were analyzed and summarized. ResultsDual-energy CT scanning technology can improve detection rate of the focal liver lesions, liver cancer recurrence lesions after local treatment and help to differentiate focal liver lesions, to stage the malignant lesions, and it also can be more accurate quantification of liver iron, fat content, indirect measurement of hepatic blood flow dynamics change situation. ConclusionDual-energy CT scanning technology can improve the diagnostic value of CT scanning technology in liver disease.
ObjectiveTo explore the utility of magnetic resonance-T1ρ-weighted imaging (T1ρWI) in the diagnosis of human primary hepatic carcinoma. MethodsNine patients were prospectively collected from West China Hospital of Sichuan University during January 2014 and June 2014, who had liver lesion that identified by the ultrasound or CT examination, and then were verified as primary hepatic carcinoma with pathological biopsy. A routine T2WI, pre-and post-contrast T1WI, pre-and post-contrast T1ρWI were performed on a 3.0 T clinical imager. The tumor-to-normal-tissue contrast was compared between pre-contrast T1ρWI/post-contrast T1ρWI and other sequences respectively, to investigate the value of T1ρWI in the diagnosis of human primary hepatic carcinoma. ResultsThe tumor-to-normal-tissue contrast of pre-and post-contrast T1WI were lower than that of pre-contrast T1ρWI (t=3.532, P=0.008; t=3.666, P=0.006), while there was no statistical difference between T2WI and pre-contrast T1ρWI (t=-1.448, P=0.186). And compared with post-contrast T1ρWI, post-contrast T1WI had lower tumor-to-normal-tissue contrast (t=3.468, P=0.008). ConclusionsT1ρWI can provide a better image of human primary hepatic carcinoma, thus T1ρWI is expected to become a new and useful method in MR scanning. It also shows potential value who can be used as an artery imaging that without using contrast agents.
ObjectiveTo investigate value of MSCT imaging on differentiating low grade pancreatic neuroendo-crine neoplasms (pNENs) from non-low grade pNENs. MethodThe clinical and CT data of 32 patients with pNENs,who were confirmed by pathological diagnosis from January 2014 to August 2015,were collected and analyzed retrospec-tively. ResultsThere were 15 patients with grade 1 in the low grade pNENs group,there were 11 patients with grade 2 and 6 patients with grade 3 in the non-low grade pNENs group.Compared with the low grade pNENs,the non-low grade pNENs had the larger diameter of the tumor (P=0.007),irregular tumor shape (P=0.006),obscure tumor margin (P=0.003),peripancreatic tissue or vascular invasion (P=0.036),lymphadenopathy (P=0.003),distant metastasis (P=0.019),lower absolute enhancement of tumor at the arterial (P=0.003) and the relative enhancement of tumor at the arterial (P=0.013). ConclusionThe analysis of MSCT features might help for differentiating low grade pNENs from non-low grade pNENs,so that more timely selection of appropriate treatment strategies would be made.