Objective To systematically evaluate the effectiveness and safety of fluoxetine in treating premature ejaculation (PE). Methods All randomized controlled trials (RCTs) on fluoxetine treating PE published from July 1996 to May 2012 were collected in the following databases: MEDLINE, EMbase, PubMed, Ovid, The Cochrane Central Register of Controlled Trials, CBM and CKNI. According to the inclusion and exclusion criteria, literature screening, data extraction and quality assessment were conducted independently by two reviewers. Then meta-analysis was performed using RevMan 5.0 software. Results A total of 6 RCTs involving 221 patients were included finally. The results of meta-analysis showed that, as for effectiveness, there was no significant difference in the intravaginal ejaculatory latency time (IELT) between the two groups before the treatment (WMD=–0.21, 95%CI −4.79 to 4.37, P=0.93), but the IELT of the fluoxetine group was obviously longer than that of the control group after the treatment, with a significant difference (WMD=134.54, 95%CI 79.78 to 189.30, Plt;0.000 01). The results of sensitivity analysis indicated that the IELT of the fluoxetine group was longer than that of the control group, with a significant difference (WMD=155.19, 95%CI 130.64 to 179.75, Plt;0.000 01). As for safety, the fluoxetine group was higher in the incidence of adverse reaction than the control group, with a significant difference (OR=5.49, 95%CI 2.43 to 12.38, Plt;0.000 1). Conclusion Current evidence indicates that fluoxetine can improve the symptoms of PE patients, obviously prolong the IELT, and improve the quality of sexual life; and it is tolerable to patients with mild adverse reactions and is suitable for long-term intake. For the limited quantity of the included studies, we herein believe that, to obtain more evidence, it is necessary to further confirm the diagnosis and therapeutic criteria of PE, to design and conduct more multicenter and large scale clinical studies by adopting the internationally recognized indexes, and to perform a long-term follow-up．
Objective To understand the adult male’s acceptance of circumcision and its influencing factors in Chongqing, so as to provide scientific evidences for developing male circumcision extension programs and health education materials. Methods The circumcision acceptance of adult males from 18 to 45 years old in Chongqing was investigated by using multistage stratified cluster sampling method. Results Among 1 502 subjects, 661 males persisted in their willingness to do circumcision, and the operation acceptance rate was 44.01%; the acceptance rate in the 18-30 age group was higher than that in the 31-45 age group; the higher the education level, the higher the acceptance of the circumcision; and workers and businessmen had greater willingness to accept than farmers. The multivariate logistic regression analysis showed that the positive factors affecting acceptance rate were “being aware that the circumcision is suitable for phimosis and redundant prepuce” (OR=21.01, 95%CI 14.21 to 31.06), “being told by friends who had circumcision before” (OR=1.65, 95%CI 1.25 to 2.19), and “being realized on the risk of phimosis and redundant prepuce” (OR=1.43, 95%CI 1.01 to 2.02); while the negative factors were “being worried about the surgical complications” (OR=0.69, 95%CI 0.50 to 0.95) and “being afraid of the ridicule from people around” (OR=0.63, 95%CI 0.40 to 0.99). Conclusion The willingness rate of adult males to accept circumcision was low in Chongqing; the publicity and education should be strengthened, and the good social atmosphere should be built for increasing the willingness rate of accepting circumcision.
Objective To understand the sexual behavior statu of married migrant workers in Chongqing, so as to provide the government with foundation for formulating related social strategies. Methods A multi-stage stratified cluster random sampling method was applied to select respondents, and the face-to-face interview was performed to investigate by trained investigators. The date was analyzed by using SAS9.0 software. Results A total of 377 married migrant workers were investigated. Among them, 226 (59.95%) lived with their spouses, of whom 13.72% had extramarital sexual behaviors, with 48.39% commercial sexual behaviors; the other 151 (40.05%) didn’t live with their spouses, of whom 49.25% had no normal sexual life for at least three months and 28.48% had extramarital sexual behaviors, with 60.47% commercial sexual behaviors. 66.41% of male migrant workers and 46.28% of female migrant workers had sexual depression, and different genders between the migrant workers were statistically significant (Plt;0.05). Conclusion There is sexual depression among married migrant workers. The related measures should be taken according to the status of their sexual behaviors, so as to improve their status of sexual depression.