ObjectiveTo explore the clinical application of comprehensive stroke units in treating patients of hemorrhagic stroke after craniotomy. MethodsWe randomly divided the 288 postoperative patients with hemorrhagic stroke treated from January 2010 to December 2013 into two groups:stroke unit group and conventional treatment group. Then we observed and compared their clinical indicators after they received different therapeutic regimens. ResultsDifferences in the national Institude of Health Stroke Scale (4.6±3.2 vs. 7.3±4.1), activities of daily living (89.3±15.6 vs. 72.5±20.3), and duration of hospital stays[(23.3±5.2) vs. (32.5±8.3) days] were significant (P<0.05) on discharge day. The infection rate during hospitalization, the scores of Glasgow outcome scale three months after leaving hospital between the stroke unit group and the conventional treatment group were statistically significant (P<0.05). There was no remarkable difference in the average cost of hospitalization between the two groups (P>0.05). ConclusionComprehensive stroke unit treatment can significantly reduce the disability rate for postoperative patients with hemorrhagic stroke, shorten the average length of stay at the hospital, save the health care resources, and improve the patients' ability to return to society as well as the satisfaction of family members.