Echocardiography is an important imaging technique in transcatheter edge-to-edge mithal valve repair (TEER). During the operation, mitral leaflets capture and clamping have the highest requirements for ultrasound image quality and should be performed under the guidance of high-quality commissural view. However, standard commissural view cannot be obtained in some patients due to cardiac enlargement, transposition or limited esophageal acoustic window. In this condition, the optimal view can be obtained by Multivue technology. This paper reports a case of successful mitral valve TEER under the real-time guidance of Multivue technology, and summarizes the key points of this technology.