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find Author "ZHU Weiping" 1 results
  • Analysis of the Correlation among Pre-S1 Antigen, HBeAg and the Results of HBV DNA in Patients with HBsAg-positive Hepatic Cirrhosis

    目的 探讨乙型肝炎病毒(HBV)表面抗原(HBsAg)阳性肝硬化患者血清中HBV前S1抗原(前S1抗原)、HBV e抗原(HBeAg)及HBV核酸定量检测(HBV DNA)相关性。 方法 2008年7月-2011年5月对97例HBsAg阳性肝硬化住院患者和50份HBsAg阴性的健康体检者血清进行前S1抗原、HBV血清标志物检测及实时荧光定量PCR检测HBV DNA结果进行分析。 结果 97份HBsAg阳性肝硬化患者血清中,前S1抗原、HBeAg及HBV DNA阳性率分别为53.6%(52/97)、22.7%(22/97)及61.8%(60/97)。22例HBeAg阳性血清中,前S1抗原阳性18例(81.8%), HBV DNA阳性20例(90.9%)。75例HBeAg阴性血清中,前S1抗原阳性34例(45.3%),HBV DNA阳性40例(53.3%),两者的前S1抗原与HBV DNA结果间都具有很好的相关性。HBV DNA含量与前S1抗原及HBeAg阳性结果显示:HBsAg阳性的肝硬化患者血清中HBV DNA阴性率为38.1%(含量<103 copies/mL),而阳性检出率HBV DNA含量主要集中在103~105 copies/mL,占81.7%(49/60),HBV DNA含量>105 copies/mL占18.3%(11/60)。 结论 HBsAg阳性的肝硬化患者血清中主要以HBV非HBeAg阳性血清学模式为主,HBV DNA阳性检出率的含量主要集中在103~105 copies/mL。前S1抗原在HBeAg阳性血清中与其含有HBsAg病毒及HBeAg阳性患者具有很好的相关性,而在HBeAg阴性血清中存在着差异。Objective To study the correlation among Pre-S1 antigen, HBeAg and HBV DNA results in patients with HBsAg-positive liver cirrhosis. Methods We retrospectively analyzed the serum pre-S1-antigen, HBV serum markers and real-time quantitative PCR HBV DNA results in 97 patients with HBsAg-positive liver cirrhosis and 50 HBsAg-negative healthy volunteers in our hospital from July 2008 to May 2011. Results Among the 97 samples of HBsAg-positive liver cirrhosis patients’ serum, the positive rates of Pre-S1 antigen, HBeAg and HBV DNA were 53.6% (52/97), 22.7% (22/97) and 61.8% (60/97), respectively. In the 22 samples of HBeAg-positive serum, the number of positive pre-S1 antigen and HBV DNA was 18 (81.8%) and 20, respectively. In the 75 samples of negative HBeAg serum, the number of positive pre-S1 antigen and HBV DNA was 34 (45.3%) and 40 (53.3%) respectively. The pre-S1 antigen was correlated well with HBV DNA results in both the two groups. HBV DNA level, pre-S1 antigen and HBeAg-positive results showed that the serum HBV DNA negative rate of HBsAg-positive patients with cirrhosis was 38.1% (<103 copies/mL), while the positive rate of HBV DNA level was mainly concentrated at 103~105 copies/mL, accounting for 81.7% (49/60), and HBV DNA level over 105 copies/mLaccounted for only 18.3% (11/60). Conclusions HBsAg-positive patients with cirrhosis mainly have a serum non-HBeAg-positive HBV serology pattern, and HBV DNA positive rate of the content is mainly concentrated at 103~105 copies/mL. There is a good correlation between pre-S1 antigen in HBeAg-positive serum and patients with HBsAg virus or positive HBeAg, while for Pre-S1 antigen in HBeAg-negative serum, it is quite different.

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