Objective The present study is to compare the quality of life and anxiety of patients with low-risk papillary thyroid microcarcinoma who received different managements to guide clinical therapy and nursing. Methods Thiswas a cohort study. Patients with low-risk papillary thyroid microcarcinoma were divided into observation group (puncture confirmed only) and surgery group (confirmed and surgery) according to their wishes, and patients’ survival quality and state of anxiety were compared by using Short-Form 36 Health Survey Scale (SF-36) and Hamilton Anxiety Scale (HAMA) between the 2 groups during the follow up period. Results There was no significant difference in physical component summary (PCS) score between the 2 groups and different observation time points (P>0.05). The mental component summary (MCS) scores and SF-36 scores of the observation group and the surgery group were different (P<0.05), and the MCS scores and SF-36 scores were different at different time points (P<0.05). The HAMA scores of patients in the observation group and the surgery group were different (P<0.001), and the change of HAMA scores in the observation group and the surgery group were different (P=0.004), but the HAMA scores at different time points were similar (P=0.152). Conclusion Surgery can effectively reduce the anxiety and improve the MCS score and quality of life.
ObjectiveTo evaluate the safty of recurrent laryngeal nerve (RLN) and parathyroid if Pseudomonas aeruginosa injection (PAI) is used after total thyroidectomy and central neck dissection (CND).MethodsFrom Mar. 2016 to Oct. 2017, we recruited 113 patients with papillary thyroid cancer (PTC) who accepted total thyroidectomy and CND. During operation, 1 mL of PAI was applied in 58 patients (local spray group) and 55 not (control group). The hoarseness, hypoparathyroidism, chylous fistula, drainage volume, hospital stay, and incidence of complications were compared between the two groups.ResultsThe two groups embraced few difference in age, gender, BMI, tumor site, the diameter of tumor and the number of metastatic and the harvested lymph nodes (P>0.05). There were nobody who has suffered in hoarseness and permanent hypoparathyroidism in both groups at any time after operation. There was no significant differences of complication between the two groups. The drainage volume at 24 h after operation in the local spraying group was more than that in the control group, and the difference was statistically significant (P=0.023). There were 2 patients had chylous fistula after surgery in the control group but none in the local spray group. The total volumes of drainage, incidence of fever and incision infection, the mean stay in the hospital, and the postoperative pain score had no statistic significance in the both groups.ConclusionAfter total thyroidectomy and CND, local spraying of PAI in the wound cavity is safe and will not damage the recurrent laryngeal nerve.